885278-75-1

Basic information

• Product Name: 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;Ethyl 2-(4-bromophenyl)-1,3-thiazole-4-carboxylate;Ethyl 2-(4-bromophenyl)thiazole-4-carboxylate
• CAS NO: 885278-75-1
• Molecular Formula: C₁₂H₁₀BrNO₂S
• Molecular Weight: 312.18
• EINECS: 200-589-5
• Product Categories: Thiazole
• Mol File: 885278-75-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 89-91 °C
• Boiling Point: 404.6 °C at 760 mmHg
• Flash Point: 198.5 °C
• Appearance: /
• Density: 1.5 g/cm³
• Vapor Pressure: 9.33E-07mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.42±0.10(Predicted)
• CAS DataBase Reference: 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(885278-75-1)
• EPA Substance Registry System: 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(885278-75-1)

Safety Data

• Hazardous Substances Data: 885278-75-1(Hazardous Substances Data)

Usage

General Description

2-(4-Bromo-phenyl)-thiazole-4-carboxylic acid ethyl ester is a chemical compound with the molecular formula C12H10BrNO2S. It is an ester derivative of thiazole carboxylic acid, and it contains a bromo-substituted phenyl group. 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER is commonly used in organic synthesis and pharmaceutical research as a building block for the preparation of various biologically active molecules, such as potential drugs and agrochemicals. Its specific chemical properties and functional groups make it a versatile intermediate in the synthesis of diverse organic compounds.

InChI:InChI=1/C12H10BrNO2S/c1-2-16-12(15)10-7-17-11(14-10)8-3-5-9(13)6-4-8/h3-7H,2H2,1H3

Upstream product

• 1221437-19-9 C₁₂H₁₂BrNO₂S 
• 623-00-7 4-bromobenzenecarbonitrile 
• 868-59-7 L-cysteine ethyl ester hydrochloride 
• 1122-91-4 4-bromo-benzaldehyde 
• 1332708-73-2 C₁₂H₁₂BrNO₂S 
• 70-23-5 ethyl Bromopyruvate 
• 26197-93-3 p-bromothiobanzamide 

Downstream Products

• 1338375-45-3 2-(4-bromophenyl)thiazole-4-carbohydrazide 
• 21160-50-9 2-(4-bromophenyl)-1,3-thiazole-4-carboxylic acid 
• 21160-53-2 2-(4-bromophenyl)-4-hydroxymethylthiazole 
• 1088410-89-2 2-(4-Bromophenyl)thiazole-4-carboxamide 

Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells

Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52 μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production. The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production.

Synthesis and biological evaluation of new 2-aryl-4-((4-aryl-1H-1,2,3-triazol-1-yl)methyl)thiazole derivatives

A series of 2-aryl-4-((4-aryl-1H-1,2,3-triazol-1-yl)methyl)thiazole derivatives (8a–p) have been synthesized. The structure of the newly synthesized compounds was determined by spectral analysis. The title compounds were screened for their preliminary ant

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

Histone deacetylase 6 (HDAC6) catalyzes the removal of an acetyl group from lysine residues of several non-histone proteins. Here we report the preparation of thiazole-, oxazole-, and oxadiazole-containing biarylhydroxamic acids by a short synthetic proce