885453-86-1Relevant articles and documents
Synthesis of the cytotoxic gitogenin 3β-O-[2-O-(α-L- rhamnopyranosyl)-β-D-galactopyranoside] and its congeners
Li, Yingxia,Zhang, Yichun,Guo, Tiantian,Guan, Huashi,Hao, Yan,Yu, Biao
, p. 775 - 782 (2007/10/03)
(25R)-5a-Spirostan-2a,3b-diol (gitogenin) 3β-O-[2-O-(α-L- rhamnopyranosyl)-β-D-galactopyranoside] (1), a cytotoxic spirostan saponin isolated from the underground parts of Hosta longipes (Liliaceae), was concisely synthesized. In this context, its congeners 2-4 were also prepared. All four compounds showed comparable potency to dioscin in inhibition against the growth of tumor cells. Georg Thieme Verlag Stuttgart.