885517-79-3

Basic information

• Product Name: (2S)-3-[5-fluoro-3-(2,6-dichlorophenyl)-2-methoxyphenyl]-1-phthalimidopropan-2-ol
• Synonyms: (2S)-3-[5-fluoro-3-(2,6-dichlorophenyl)-2-methoxyphenyl]-1-phthalimidopropan-2-ol
• CAS NO: 885517-79-3
• Molecular Weight: 474.316
• Mol File: 885517-79-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S)-3-[5-fluoro-3-(2,6-dichlorophenyl)-2-methoxyphenyl]-1-phthalimidopropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-3-[5-fluoro-3-(2,6-dichlorophenyl)-2-methoxyphenyl]-1-phthalimidopropan-2-ol(885517-79-3)
• EPA Substance Registry System: (2S)-3-[5-fluoro-3-(2,6-dichlorophenyl)-2-methoxyphenyl]-1-phthalimidopropan-2-ol(885517-79-3)

Safety Data

• Hazardous Substances Data: 885517-79-3(Hazardous Substances Data)

Upstream product

• 136918-14-4 phthalimide 
• 852121-36-9 (S)-2-((2',6'-dichloro-5-fluoro-2-methoxybiphenyl-3-yl)methyl)oxirane 
• 1074-82-4 potassium phtalimide 
• 179897-94-0 (5-fluoro-2-methoxyphenyl)boronic acid 
• 19393-92-1 1-bromo-2,6-dichlorobenzene 
• 852112-78-8 1-methoxy-2-bromo-4-fluoro-2',6'-dichlorobiphenyl 
• 70987-78-9 (S)-Glycidyl tosylate 
• 885517-77-1 2',6'-dichloro-5-fluoro-2-methoxybiphenyl 

Relevant articles and documents

Development of a new practical synthesis of a 5-HT2C receptor agonist

A new practical synthesis of a 5-HT2C receptor agonist has been developed and implemented on multikilogram scale. The key step, the selective epoxide opening in the glycidyl tosylate with the aryl Grignard reagent, allowed the incorporation of this commercially available chiral C3 synthon into the molecule and elaboration of the resulting intermediate into the target aminomethyldihydrobenzofuran without loss of enantiomeric purity.