885521-40-4 Usage
General Description
3-Bromo-4-Chloro (1H) Indazole is a synthetic compound classified under the organic group of indazoles. Its chemical formula is C7H4BrClN2, and is primarily used in various research and development applications. As a heterocyclic aromatic compound, it is composed of a fused six-member benzene ring and a nitrogen-containing pyrazole ring. Besides, the presence of bromo and chloro substituents increases its reactivity, making it a valuable starting substrate for synthesizing diverse indazole-based molecules with potential applications in medicinal chemistry, biotechnology, and pharmaceutical industry. However, due to its chemical nature, it must be handled under appropriate safety precautions to avoid any potential hazards or adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 885521-40-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,5,2 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 885521-40:
(8*8)+(7*8)+(6*5)+(5*5)+(4*2)+(3*1)+(2*4)+(1*0)=194
194 % 10 = 4
So 885521-40-4 is a valid CAS Registry Number.
885521-40-4Relevant articles and documents
Direct access to 3-aminoindazoles by Buchwald-Hartwig C-N coupling reaction
Lohou, Elodie,Collot, Valeri,Stiebing, Silvia,Rault, Sylvain
, p. 2651 - 2663 (2011)
An efficient synthesis of various N-substituted 3-aminoindazoles using Buchwald-Hartwig C-N coupling reaction is described. Several parameters were varied, including the nature of the halogen atom and the protecting group of the starting materials, as well as the effects of the catalyst system, base, solvent, and reaction time. The efficiency of microwave versus conventional heating was also compared to test the outcome of the reaction. Thus, by applying this recent knowledge about metal-catalyzed aminations, an alternative for the direct synthesis of primary 3-aminoindazoles has been provided. Georg Thieme Verlag Stuttgart. New York.