88569-39-5

Basic information

• Product Name: 7-chloro-6-fluoro-1,4-dihydro-1-(methylamino)-4-oxoquinoline-3-carboxylic acid
• Synonyms: 7-chloro-6-fluoro-1,4-dihydro-1-(methylamino)-4-oxoquinoline-3-carboxylic acid;7-Chloro-6-fluoro-1,4-dihydro-1-(methylamino)-4-oxo-3-quinolinecarboxylic acid;7-CHLORO-6-FLUORO-1-(METHYLAMINO)-4-OXOQUINOLINE-3-CARBOXYLIC ACID(WXG01227);7-CHLORO-6-FLUORO-1-(METHYLAMINO)-4-OXOQUINOLINE-3-CARBOXYLIC ACID
• CAS NO: 88569-39-5
• Molecular Formula: C₁₁H₈ClFN₂O₃
• Molecular Weight: 270.6442232
• EINECS: 289-428-9
• Mol File: 88569-39-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 443°C at 760 mmHg
• Flash Point: 221.7°C
• Appearance: /
• Density: 1.61g/cm³
• Vapor Pressure: 1.26E-08mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: 7-chloro-6-fluoro-1,4-dihydro-1-(methylamino)-4-oxoquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-6-fluoro-1,4-dihydro-1-(methylamino)-4-oxoquinoline-3-carboxylic acid(88569-39-5)
• EPA Substance Registry System: 7-chloro-6-fluoro-1,4-dihydro-1-(methylamino)-4-oxoquinoline-3-carboxylic acid(88569-39-5)

Safety Data

• Hazardous Substances Data: 88569-39-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H8ClFN2O3/c1-14-15-4-6(11(17)18)10(16)5-2-8(13)7(12)3-9(5)15/h2-4,14H,1H3,(H,17,18)

Upstream product

• 75073-15-3 ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate 
• 88569-38-4 ethyl 7-chloro-6-fluoro-1-[formyl(2-propenyl)amino]-1,4-dihydro-4-oxo-3-quinolinecarboxylate 
• 109308-97-6 ethyl 3-N-formyl-N-methylhydrazyl-2-(2,4-dichloro-5-fluoro)benzoylacrylate 
• 86483-51-4 ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate 
• 704-10-9 2,4-dichloro-5-fluoroacetophenone 
• 86483-52-5 2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester 
• 102618-08-6 2-(2,4-Dichlor-5-fluor-benzoyl)-3-(2-formyl-2-methylhydrazino)acrylsaeure-ethylester 
• 88569-33-9 ethyl 7-chloro-6-fluoro-1-(formylamino)-1,4-dihydro-4-oxo-3-quinolinecarboxylate 
• 88569-30-6 ethyl 1-amino-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate 
• 88569-34-0 ethyl 1-(N-formyl-N-methyl)amino-6-fluoro-7-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylate 

Downstream Products

• 88569-57-7 A 56559 
• 86393-37-5 amifloxacin 
• 88569-53-3 6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 4'-oxide 
• 104-15-4 toluene-4-sulfonic acid 
• 89990-94-3 6-Fluoro-1-methylamino-7-(4-methyl-[1,4]diazepan-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 

Relevant articles and documents

Cycloaracylation of Enamines,II. - Synthesis of 1-Amino-4-quinolone-3-carboxylic Acids

The 2-benzoyl-3-hydrazinoacrylic esters 3, 11, 17, and 23 are obtained by the reactions of 2-chloro-5-nitrobenzoyl chloride (1) with the enehydrazinocarboxylic esters 2 and 2-benzoyl-3-ethoxyacrylic esters 9 with hydrazine derivatives 10, 16, and 22.After cyclocondensation, the above esters afford 1-aminoquinolonecarboxylic esters 4, 12, 18, and 24, which are hydrolyzed to give the corresponding 1-aminoquinolonecarboxylic acids 5, 13, 19, and 26.The 1-amino-7-haloquinolonecarboxylic acids 13a-f, 19a-f, and 26b react with aliphatic amines to afford 1,7-diaminoquinolonecarboxylic acids 30c-m, which possess a high level of bactericidal activity.

A regiospecific synthesis of 1-methylamino-6-fluoro-7-(4-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoli ne-3-carboxylic acid

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