886206-84-4Relevant articles and documents
Conformational Analysis of Acyclic α-Fluoro Sulfur Motifs
Erdeljac, Nathalie,Mück-Lichtenfeld, Christian,Daniliuc, Constantin G.,Gilmour, Ryan
, p. 13704 - 13715 (2020/10/02)
Bioactive small molecules containing α-fluoro sulfur motifs [RS(O)nCH2F] are appearing with increasing frequency in the pharmaceutical and agrochemical sectors. Prominent examples include the anti-asthma drug Flovent and t
Expedient synthesis of α-substituted fluoroethenes
Mandal, Samir K.,Ghosh, Arun K.,Kumar, Rakesh,Zajc, Barbara
scheme or table, p. 3164 - 3167 (2012/06/04)
A mild and efficient synthesis of 1-aryl-1-fluoroethenes from benzothiazolyl (aryl)fluoromethyl sulfones and paraformaldehyde, under DBU- or Cs2CO3-mediated conditions at room temperature, is described. A comparable diethyl fluoro(naphthalen-2-yl)methylphosphonate reagent does not react with paraformaldehyde under these mild conditions. The utility of the methodology for synthesis of terminal α-fluoroalkenes bearing electron-withdrawing functionalities is also shown.