886363-18-4 Usage
General Description
4-(5'-Indole)benzoic acid, also known as 4-Indolecarboxylic acid, is an organic compound primarily known for its use in scientific and biochemical research, particularly in plant and microbiology. 4-(5'-Indole)benzoic acid belongs to the family of benzoic acids and derivatives, and its structure comprises an indole moiety linked to a benzoic acid group. 4-(5'-Indole)benzoic acid is often used as a reagent or intermediate in the synthesis of other complex organic compounds. It is also significant in plant physiology because it is a precursor of indole-3-acetic acid, the primary natural auxin or plant hormone. Study of this compound's properties and effects plays an integral role in understanding various biochemical pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 886363-18-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,3,6 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 886363-18:
(8*8)+(7*8)+(6*6)+(5*3)+(4*6)+(3*3)+(2*1)+(1*8)=214
214 % 10 = 4
So 886363-18-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H11NO2/c17-15(18)11-3-1-10(2-4-11)12-5-6-14-13(9-12)7-8-16-14/h1-9,16H,(H,17,18)
886363-18-4Relevant articles and documents
Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors
Pu, Chunlan,Luo, Rong-Hua,Zhang, Mengqi,Hou, Xueyan,Yan, Guoyi,Luo, Jiang,Zheng, Yong-Tang,Li, Rui
, p. 4150 - 4155 (2017/08/22)
The crystal structure of viral infectivity factor (Vif) was reported recently, which makes it possible to design new inhibitors against Vif by structure-based drug design. Through analysis of the protein surface of Vif, the C2 pocket located in the N-terminal was found, which is suit for developing small molecular inhibitors. Then, in our article, fragment-based virtual screening (FBVS) was conducted and a series of fragments was obtained, among which, Zif-1 bearing indole scaffold and pyridine ring can form H-bonds with Tyr148 and Ile155. Subsequently, 19 derivatives of Zif-1 were synthesized. Through the immune-fluorescence staining and Western blot assays, Zif-15 shows potent activity in inhibiting Vif-mediated A3G degradation. Further docking experiment shows that Zif-15 form H-bond interactions with residues His139, Tyr148 and Ile155. Therefore, Zif-15 is a promising lead compound against Vif that can be used to treat AIDS.
