886365-06-6

Basic information

• Product Name: 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;5-BroMo-4-Methyl-Pyridine-2-Carboxylicycid Methylester;Methyl 5-broMo-4-Methylpyridine-2-carboxylate;Methyl 5-broMo-4-Methylpicolinate
• CAS NO: 886365-06-6
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• Product Categories: Heterocycle-Pyridine series
• Mol File: 886365-06-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 335ºC at 760 mmHg
• Flash Point: 156.4ºC
• Appearance: /
• Density: 1.692g/cm3
• Vapor Pressure: 4.86E-05mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.16±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER(886365-06-6)
• EPA Substance Registry System: 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER(886365-06-6)

Safety Data

• Hazardous Substances Data: 886365-06-6(Hazardous Substances Data)

Usage

General Description

5-Bromo-4-methyl-pyridine-2-carboxylic acid methyl ester is a chemical compound with the molecular formula C8H8BrNO2. It is a methyl ester derivative of 5-bromo-4-methyl-2-pyridinecarboxylic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 5-Bromo-4-methyl-pyridine-2-carboxylic acid methyl ester is a white to off-white solid with a molecular weight of 227.06 g/mol. It is primarily used as a building block in organic synthesis and has potential applications in the pharmaceutical industry for the production of new drug compounds. Additionally, it may also have uses in the development of agrochemicals and other specialty chemicals.

InChI:InChI=1/C7H6BrNO2/c1-4-2-6(7(10)11)9-3-5(4)8/h2-3H,1H3,(H,10,11)

Upstream product

• 67-56-1 methanol 
• 1122090-38-3 potassium 5-bromo-4-methylpyridine-2-carboxylic acid 
• 886365-02-2 5-bromo-4-methyl-pyridine-2-carboxylic acid 
• 3430-26-0 2,5-Dibromo-4-methylpyridine 
• 1122090-37-2 5-bromo-4-methyl-2-vinyl-pyridine 

Downstream Products

• 886365-02-2 5-bromo-4-methyl-pyridine-2-carboxylic acid 
• 1432055-30-5 methyl 5-(3-iodo-4-methoxyphenyl)-4-methylpyridine-2-carboxylate 
• 1432055-31-6 methyl 5-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-methylpyridine-2-carboxylate 
• 1432055-29-2 methyl 5-(4-methoxyphenyl)-4-methylpyridine-2-carboxylate 
• 1374135-71-3 methyl 5-(2-fluoro-5-iodo-4-methoxyphenyl)-4-methylpyridine-2-carboxylate 
• 1374134-95-8 methyl 5-(2-fluoro-4-methoxyphenyl)-4-methylpyridine-2-carboxylate 

Relevant articles and documents

DIAZAINDOLE INHIBITORS OF CRAC

Disclosed are compounds of Formula (I): useful for treatment of autoimmune and inflammatory diseases associated with IL-2 inhibition via modulation of calcium release-activated calcium (CRAC) channels. Also disclosed are methods of making and using the compounds for treatment of diseases associated with CRAC channels.

4-AZAINDOLE INHIBITORS OF CRAC

Disclosed are compounds of Formula (I): useful for treatment of autoimmune and inflammatory diseases associated with IL-2 inhibition via modulation of calcium release-activated calcium (CRAC) channels. Also disclosed are methods of making and using the compounds for treatment of diseases associated with CRAC channels.

INDOLE DERIVATIVES AS CRAC MODULATORS

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).