886371-24-0 Usage
Description
C-(3-Trifluoromethyl-pyridin-2-yl)-methylamine is an organic compound characterized by the presence of a trifluoromethyl group attached to a pyridine ring, with a methylamine group attached to the carbon atom. C-(3-Trifluoromethyl-pyridin-2-yl)-methylamine is known for its potential applications in the synthesis of various pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
C-(3-Trifluoromethyl-pyridin-2-yl)-methylamine is used as a key intermediate in the discovery and synthesis of 4-Amino-8-quinoline carboxamides. These compounds have been identified as novel, submicromolar inhibitors of the NAD-hydrolyzing enzyme CD38, which plays a crucial role in various cellular processes, including immune response and cell cycle regulation. Inhibition of CD38 has been shown to have potential therapeutic benefits in the treatment of various diseases, such as cancer and neurodegenerative disorders.
In the context of the provided materials, C-(3-Trifluoromethyl-pyridin-2-yl)-methylamine serves as an essential building block in the development of new and effective inhibitors targeting CD38, contributing to advancements in medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 886371-24-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,3,7 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 886371-24:
(8*8)+(7*8)+(6*6)+(5*3)+(4*7)+(3*1)+(2*2)+(1*4)=210
210 % 10 = 0
So 886371-24-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H7F3N2/c8-7(9,10)5-2-1-3-12-6(5)4-11/h1-3H,4,11H2
886371-24-0Relevant articles and documents
Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists
Jiang, Rong,Song, Xinyi,Bali, Purva,Smith, Anthony,Bayona, Claudia Ruiz,Lin, Li,Cameron, Michael D.,McDonald, Patricia H.,Kenny, Paul J.,Kamenecka, Theodore M.
scheme or table, p. 3890 - 3894 (2012/07/13)
A series of orexin receptor antagonists was synthesized based on a substituted piperidine scaffold. Through traditional medicinal chemistry structure-activity relationships (SAR), installation of various groups at the 3-6-positions of the piperidine led to modest enhancement in receptor selectivity. Compounds were profiled in vivo for plasma and brain levels in order to identify candidates suitable for efficacy in a model of drug addiction.
