886373-00-8

Basic information

• Product Name: 5-Bromo-2-ethoxypyridin-3-amine
• Synonyms: 5-Bromo-2-ethoxypyridin-3-amine;3-Amino-5-bromo-2-ethoxypyridine
• CAS NO: 886373-00-8
• Molecular Formula: C₇H₉BrN₂O
• Molecular Weight: 217.06316
• Mol File: 886373-00-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 5-Bromo-2-ethoxypyridin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-ethoxypyridin-3-amine(886373-00-8)
• EPA Substance Registry System: 5-Bromo-2-ethoxypyridin-3-amine(886373-00-8)

Safety Data

• Hazardous Substances Data: 886373-00-8(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-ethoxypyridin-3-amine, also known as 5-Bromo-2-ethoxypicolin-3-amine, is a chemical compound with the formula C9H11BrN2O. It is a pyridine derivative with a bromine atom and an ethoxy group attached to the second and third carbon atoms, respectively. 5-Bromo-2-ethoxypyridin-3-amine is commonly used in organic synthesis and can be employed as a building block in the preparation of various pharmaceuticals, agrochemicals, and functional materials. It is also used in the synthesis of CCR3 antagonists, which have potential applications in the treatment of inflammatory and allergic diseases. 5-Bromo-2-ethoxypyridin-3-amine is a valuable intermediate in chemical research and has diverse potential applications in the field of medicinal chemistry.

Upstream product

• 886372-76-5 5-bromo-2-ethoxy-3-nitropyridine 
• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 

Downstream Products

• 1086063-48-0 N-[5-bromo-2-(ethyloxy)-3-pyridinyl]benzenesulfonamide 
• 1366129-92-1 N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-(ethyloxy)-3-pyridinyl}benzenesulfonamide 
• 1366131-84-1 N-[2-(ethyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]benzenesulfonamide 
• 848243-20-9 5-bromo-2-ethoxy-3-iodopyridine 

Relevant articles and documents

Discovery of 3-Quinazolin-4(3 H)-on-3-yl-2, N-dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors

Phosphoinositide 3-kinases (PI3Ks) mediate a series of events related to cell growth, proliferation, survival, and differentiation. Overexpression of PI3Ks can lead to the dysregulation of cell homeostasis and cause tumorigenesis. In this study, rationally designed compounds were investigated as PI3Kα-selective inhibitors. Our efforts culminated in the discovery of a series of quinazolin-4(3H)-one derivatives with 2-substituted-N-methylpropanamide substitutions as PI3Kα-selective inhibitors. The best compound, 10, has PI3Kα enzymatic and cellular IC50 values of 1.8 and 12.1 nM, respectively. It exhibits biochemical selectivities for PI3Kα over PI3Kβ/δ/γof 150/7.72/7.67-fold and cellular selectivities of 115/15.1/>826-fold, respectively. Compound 10 is 59% orally bioavailable with a dose-normalized AUC of 3090 nM. These effects translated into in vivo conditions, as 10 significantly time- and dose-dependently inhibited phosphorylation of Akt in BT-474 subcutaneous xenograft mice and inhibited tumor growth.

BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES

The invention is directed to compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.