886576-75-6

Basic information

• Product Name: benzyl 2-methylpyrrolidine-1-carboxylate
• Synonyms: benzyl 2-methylpyrrolidine-1-carboxylate;2-Methyl-1-pyrrolidinecarboxylic acid phenylmethyl ester;1-Pyrrolidinecarboxylic acid, 2-Methyl-, phenylMethyl ester
• CAS NO: 886576-75-6
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.28
• Mol File: 886576-75-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.107
• Storage Temp.: 2-8°C
• CAS DataBase Reference: benzyl 2-methylpyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-methylpyrrolidine-1-carboxylate(886576-75-6)
• EPA Substance Registry System: benzyl 2-methylpyrrolidine-1-carboxylate(886576-75-6)

Safety Data

• Hazardous Substances Data: 886576-75-6(Hazardous Substances Data)

Usage

Description

Benzyl 2-methylpyrrolidine-1-carboxylate, also known as benzydamine, is a chemical compound with analgesic and anti-inflammatory properties. It is commonly used in topical treatments for muscle and joint pain, as well as sore throat and mouth ulcers. Benzydamine works by inhibiting the production of prostaglandins and decreasing the sensitivity of pain receptors, ultimately reducing pain and inflammation. Additionally, it has local anesthetic properties that can provide relief from discomfort. Benzydamine is considered safe for use and is available in various pharmaceutical formulations, such as gels, sprays, and lozenges.

Uses

Used in Pharmaceutical Industry:
Benzyl 2-methylpyrrolidine-1-carboxylate is used as an analgesic and anti-inflammatory agent for the treatment of muscle and joint pain, sore throat, and mouth ulcers. It is effective in reducing pain and inflammation by inhibiting prostaglandin production and decreasing the sensitivity of pain receptors.
Used in Topical Treatments:
Benzyl 2-methylpyrrolidine-1-carboxylate is used as a topical treatment for muscle and joint pain, sore throat, and mouth ulcers. It is available in various pharmaceutical formulations, such as gels, sprays, and lozenges, providing relief from discomfort and inflammation.
Used in Pain Management:
Benzyl 2-methylpyrrolidine-1-carboxylate is used as a pain management agent, providing relief from discomfort and inflammation associated with muscle and joint pain, sore throat, and mouth ulcers. Its local anesthetic properties contribute to its effectiveness in pain relief.

Upstream product

• 86136-88-1 pent-4-enylcarbamic acid benzyl ester 
• 501-53-1 benzyl chloroformate 
• 765-38-8 (S)-2-methylpyrrolidine 
• 765-38-8 2-methyl-1-pyrrolidine 
• 7736-25-6 2-(pent-4-enyl)-isoindoline-1,3-dione 
• 821-09-0 n-Pent-4-enyl alcohol 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 61350-66-1 (S)-2-(chloromethyl)-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 22537-07-1 4-pentenyl-1-amine 

Relevant articles and documents

Acylative kinetic resolution of racemic methyl-substituted cyclic alkylamines with 2,5-dioxopyrrolidin-1-yl (: R)-2-phenoxypropanoate

The diastereoselective acylation of a number of racemic methyl-substituted cyclic alkylamines with active esters of 2-phenoxypropanoic acid was studied in detail. The ester of (R)-2-phenoxypropanoic acid and N-hydroxysuccinimide was found to be the most selective agent. The highest stereoselectivity was observed in the kinetic resolution of racemic 2-methylpiperidine in toluene at -40 °C (selectivity factor s = 73) with the predominant formation of (R,R)-amide (93.7% de). To explain the observed stereoselectivity, DFT modelling of the transition states in the reactions of the title acylating agent with 2-methylpiperidine and 2-methylpyrrolidine was performed. The calculated values were in good agreement with experimental data. It has been demonstrated that the acylation proceeds via a concerted mechanism, in which the addition of an amine occurs simultaneously with the elimination of the hydroxysuccinimide fragment. The high stereoselectivity of the (R,R)-amide formation is largely ensured by the lower steric hindrances in the transition states as compared to the formation of (R,S)-amide.

Asymmetric intramolecular hydroamination of alkenes in mild and wet conditions - Structure and reactivity of cationic binuclear gold(I) catalysts

A selected diphosphine binuclear gold(I) chloride complex was combined with a silver salt to catalyze efficiently, for the first time, the asymmetric intramolecular hydroamination of alkenes with high conversions and enantioselectivities, in mild conditions and in presence of water. Both enantiomers of the products could be obtained by controlling the molecular ion-pairs through the solvent polarity. The gold(I) cationic active species was characterized unambiguously at the solid state by X-ray analysis and in solution by DOSY 1H NMR experiments. No contribution of silver chloride was observed on the bonding mode of the catalyst.

Room temperature palladium-catalyzed intramolecular hydroamination of unactivated alkenes

A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes is described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. The formation of hydroamination products rather than oxidative amination products is due to the use of a tridentate ligand on Pd which effectively inhibits β-hydride elimination. Copyright