886990-15-4Relevant articles and documents
Carboxylate bioisosteres of gabapentin
Burgos-Lepley, Carmen E.,Thompson, Lisa R.,Kneen, Clare O.,Osborne, Simon A.,Bryans, Justin S.,Capiris, Thomas,Suman-Chauhan, Nirmala,Dooley, David J.,Donovan, Cindy M.,Field, Mark J.,Vartanian, Mark G.,Kinsora, Jack J.,Lotarski, Susan M.,El-Kattan, Ayman,Walters, Karen,Cherukury, Madhu,Taylor, Charles P.,Wustrow, David J.,Schwarz, Jacob B.
, p. 2333 - 2336 (2006)
A series of carboxylate bioisosteres of structures related to gabapentin 1 have been prepared. When the carboxylate was replaced by a tetrazole, this group was recognized by the α2-δ protein. Further characterization of α2-δ binding compounds 14a and 14b revealed a similar pattern of functional in vitro and in vivo activity to gabapentin 1.
