886990-81-4 Usage
General Description
1H-Indole-7-methanol, a-[(1R,2Z)-2-[[[S(S)]-N-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl]-S-(4-methylphenyl)sulfonimidoyl]methylene]cyclohexyl]-2,3-dihydro-, (aR)- is a complex chemical compound with various functional groups and stereochemistry. It is a derivative of 1H-indole-7-methanol with a sulfonyl imine group and a cyclohexyl ring, among other substituents. The presence of both a sulfonyl imine and a cyclohexyl ring gives this compound potential pharmaceutical and biological activities, and its stereochemistry may have a significant impact on its interactions and reactivity with other molecules. 1H-Indole-7-methanol,
a-[(1R,2Z)-2-[[[S(S)]-N-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]me
thyl]-2-methylpropyl]-S-(4-methylphenyl)sulfonimidoyl]methylene]cyclohe
xyl]-2,3-dihydro-, (aR)- may be of interest in the development of new drugs or as a research tool in chemical and pharmaceutical studies.
Check Digit Verification of cas no
The CAS Registry Mumber 886990-81-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,9,9 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 886990-81:
(8*8)+(7*8)+(6*6)+(5*9)+(4*9)+(3*0)+(2*8)+(1*1)=254
254 % 10 = 4
So 886990-81-4 is a valid CAS Registry Number.
886990-81-4Relevant articles and documents
Asymmetric synthesis of highly substituted azapolycyclic compounds via 2-alkenyl sulfoximines: Potential scaffolds for peptide mimetics
Reggelin, Michael,Junker, Bernd,Heinrich, Timo,Slavik, Stefan,Buehle, Philipp
, p. 4023 - 4034 (2007/10/03)
The application of metalated, enantiomerically pure acyclic and cyclic 2-alkenyl sulfoximines for the synthesis of highly substituted aza(poly)cyclic ring systems is described. The method relies on a one-pot combination of a reagent-controlled allyl transfer reaction to α- or β-amino aldehydes, followed by a Michael-type cyclization of the intermediate vinyl sulfoximines generated in the first step. The sulfur-free target compounds are preferentially obtained by samarium iodide treatment of the sulfonimidoyl substituted heterocycles. In addition to this methodological work, initial results on the biological activity of selected examples are reported. Furthermore, a concept for the transformation of peptidic lead structures into non-peptide mimetics is described, and the relevance of the new approach to highly substituted azaheterocycles in this context is discussed.
