88709-18-6

Basic information

• Product Name: Benzoic acid, 2-ethoxy-4-methyl-
• CAS NO: 88709-18-6
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 88709-18-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-ethoxy-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-ethoxy-4-methyl-(88709-18-6)
• EPA Substance Registry System: Benzoic acid, 2-ethoxy-4-methyl-(88709-18-6)

Safety Data

• Hazardous Substances Data: 88709-18-6(Hazardous Substances Data)

Upstream product

• 50-85-1 2-hydroxy-p-toluic acid 
• 105-58-8 Diethyl carbonate 
• 64-19-7 acetic acid 

Downstream Products

• 99469-99-5 2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid 
• 88709-20-0 2-ethoxy-4-cyanomethyl-benzoic acid 
• 88709-19-7 ethyl 4-bromomethylsalicylic acid 

Relevant articles and documents

Synthesis method of 3-ethoxy-4-ethoxycarbonyl phenylacetic acid

The invention relates to a synthesis method of 3-ethoxy-4-ethoxycarbonyl phenylacetic acid, and belongs to the technical field of medicine synthesis. In order to solve the problems of long reaction route and low yield in the prior art, the invention provides the synthesis method of 3-ethoxy-4-ethoxycarbonyl phenylacetic acid, which comprises the following steps: under the actions of a catalytic amount of phase transfer catalyst and cocatalyst, carrying out etherification and esterification reaction on 4-methylsalicylic acid and diethyl carbonate in a water-insoluble solvent to obtain a corresponding intermediate is obtained, in the presence of lithium diisopropylamide, carrying out methylation reaction on the intermediate and dimethyl carbonate or diethyl carbonate at the temperature of -50 DEG C or below, and carrying out acid regulation treatment to control the pH value of the system to be 3.5 or below, thereby obtaining the corresponding product compound 3-ethoxy-4-ethoxycarbonylphenylacetic acid shown in the formula III. According to the method, the operation of each step of reaction post-treatment is simple and easy, the method has the advantage of short reaction route, and the yield of the final product is high.