88721-77-1

Basic information

• Product Name: 4-amino-N-(1-azabicyclo[3.3.1]non-6-yl)-3-chloro-2-methoxy-benzamide
• Synonyms: 4-amino-N-(1-azabicyclo[3.3.1]non-6-yl)-3-chloro-2-methoxy-benzamide
• CAS NO: 88721-77-1
• Molecular Formula: C16H22ClN3O2
• Molecular Weight: 323.8178
• Mol File: 88721-77-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 469.2°Cat760mmHg
• Flash Point: 237.6°C
• Appearance: /
• Density: 1.3g/cm³
• CAS DataBase Reference: 4-amino-N-(1-azabicyclo[3.3.1]non-6-yl)-3-chloro-2-methoxy-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-N-(1-azabicyclo[3.3.1]non-6-yl)-3-chloro-2-methoxy-benzamide(88721-77-1)
• EPA Substance Registry System: 4-amino-N-(1-azabicyclo[3.3.1]non-6-yl)-3-chloro-2-methoxy-benzamide(88721-77-1)

Safety Data

• Hazardous Substances Data: 88721-77-1(Hazardous Substances Data)

Upstream product

• 4516-32-9 4-acetylamino-5-chloro-2-methoxy-benzoyl chloride 
• 127642-61-9 1-Aza-bicyclo[3.3.1]non-4-ylamine 
• 88721-85-1 (RS)-endo-4-amino-1-azabicyclo[3.3.1]nonane 
• 127642-61-9 (1R,4R,5R)-(1-Aza-bicyclo[3.3.1]non-4-yl)amine 
• 127642-61-9 1-Aza-bicyclo[3.3.1]non-4-ylamine 

Relevant articles and documents

Synthesis

The present invention provides an improved process for the production of [(±)-endo]-4-amino-5-chloro-2-methoxy-N-(1-azabicyclo[3.3.1]non-4-yl)benzamide hydrochloride, compositions thereof, and intermediates thereto.

Substituted Benzamides with Conformationally Restricted Side Chains. 5. Azabicyclo Derivatives as 5-HT4 Receptor Agonists and Gastric Motility Stimulants

The syntheses of benzamides containing azabicyclo side chains and their 5-HT4 receptor agonist and 5-HT3 receptor antagonist properties are described.These compounds were designed to mimic higher energy conformations of quinol