88755-16-2

Basic information

• Product Name: OXO(3,4,5-TRIMETHOXYPHENYL)ACETIC ACID
• Synonyms: OXO(3,4,5-TRIMETHOXYPHENYL)ACETIC ACID;2-Oxo-2-(3,4,5-trimethoxyphenyl)acetic acid;2-(3,4,5-Trimethoxyphenyl)-2-oxoacetic acid;3,4,5-Trimethoxy-benzoylformic acid
• CAS NO: 88755-16-2
• Molecular Formula: C₁₁H₁₂O₆
• Molecular Weight: 240.21
• Mol File: 88755-16-2.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: OXO(3,4,5-TRIMETHOXYPHENYL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: OXO(3,4,5-TRIMETHOXYPHENYL)ACETIC ACID(88755-16-2)
• EPA Substance Registry System: OXO(3,4,5-TRIMETHOXYPHENYL)ACETIC ACID(88755-16-2)

Safety Data

• Hazardous Substances Data: 88755-16-2(Hazardous Substances Data)

Usage

General Description

OXO(3,4,5-TRIMETHOXYPHENYL)ACETIC ACID is an organic compound with the chemical formula C11H14O5. It is also known as ferulic acid, and is commonly found in the cell walls of plants such as rice, wheat, and oats. OXO(3,4,5-TRIMETHOXYPHENYL)ACETIC ACID has antioxidant properties, and has been studied for its potential health benefits, including its ability to protect against oxidative stress and inflammation. It has also been investigated for its potential anti-cancer properties, as well as its ability to protect against cardiovascular disease and diabetes. OXO(3,4,5-TRIMETHOXYPHENYL)ACETIC ACID is commonly used as an ingredient in skincare and cosmetic products due to its antioxidant and anti-aging properties.

Upstream product

• 861569-57-5 (3,4,5-trimethoxy-phenyl)-glyoxylic acid amide 
• 109475-81-2 1-(3,4,5-trimethoxy-phenacyl)-pyridinium; chloride 
• 105905-64-4 2-chloro-1-(3,4,5-trimethoxy-phenyl)-ethanone 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 5955-75-9 3,4,5-trimethoxybenzoyl cyanide 
• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 14326-13-7 1-(1-hydroxy-2-nitroethyl)-3,4,5-trimethoxybenzene 
• 88775-41-1 4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyramide 
• 77-78-1 dimethyl sulfate 
• 102460-79-7 2-(4-dimethylamino-phenylimino)-3-oxo-3-(3,4,5-trimethoxy-phenyl)-propionitrile 

Downstream Products

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Relevant articles and documents

Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35

FK506-binding protein 35, FKBP35, has been implicated as an essential malarial enzyme. Rapamycin and FK506 exhibit antiplasmodium activity in cultured parasites. However, due to the highly conserved nature of the binding pockets of FKBPs and the immunosuppressive properties of these drugs, there is a need for compounds that selectively inhibit FKBP35 and lack the undesired side effects. In contrast to human FKBPs, FKBP35 contains a cysteine, C106, adjacent to the rapamycin binding pocket, providing an opportunity to develop targeted covalent inhibitors of Plasmodium FKBP35. Here, we synthesize inhibitors of FKBP35, show that they directly bind FKBP35 in a model cellular setting, selectively covalently modify C106, and exhibit antiplasmodium activity in blood-stage cultured parasites.

Method for preparing aromatic glyoxylic acid by oxidizing aromatic ethyl ketone with selenium dioxide

The invention discloses a method for preparing aromatic glyoxylic acid by oxidizing aromatic ethyl ketone with selenium dioxide. The method comprises the following steps: dissolving aromatic ethyl ketone in an alkaline organic solvent, carrying out stirri

Bioinspired Radical Stetter Reaction: Radical Umpolung Enabled by Ion-Pair Photocatalysis

A bioinspired, intermolecular radical Stetter reaction of α-keto acids and aldehydes is disclosed that is contingent on a formal “radical umpolung” concept. Enabled by secondary amine activation, electrostatic recognition ensures that the α-ketocarboxylic acids, which function as latent acyl radicals, are proximal to the in situ generated iminium salts. This photoactive contact ion pair is an electron donor–acceptor (EDA) complex, and undergoes facile single electron transfer (SET) and rapid decarboxylation prior to radical–radical recombination. Importantly, decarbonylation is mitigated by this strategy. The initial computational validation on which the process is predicated matches closely with experiment. Synergising organo- and photocatalysis activation principles finally expands the mechanistic and synthetic scope of the classic Stetter reaction to include α,β-unsaturated aldehydes as acceptors.