887579-69-3

Basic information

• Product Name: TERT-BUTYL-5-CYANONICOTINATE
• Synonyms: TERT-BUTYL-5-CYANONICOTINATE
• CAS NO: 887579-69-3
• Molecular Formula: C11H12N2O2
• Molecular Weight: 204.23
• Mol File: 887579-69-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TERT-BUTYL-5-CYANONICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL-5-CYANONICOTINATE(887579-69-3)
• EPA Substance Registry System: TERT-BUTYL-5-CYANONICOTINATE(887579-69-3)

Safety Data

• Hazardous Substances Data: 887579-69-3(Hazardous Substances Data)

Upstream product

• 263270-02-6 tert-butyl 5-bromopyridine-3-carboxylate 
• 557-21-1 zinc(II) cyanide 
• 402718-29-0 3-cyanopyridine-5-boronic acid pinacol ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 

Relevant articles and documents

A larene/ fragrant mixedsurrounds uncle butanol method for preparing ester compounds

The invention discloses a preparation method of an aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound. The preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound comprises the following steps of: firstly, under stirring condition, adding aromatic heterocycle borate compound or aromatic ring boric acid compound and di-tert-butyl dicarbonate ester into a solvent, and then adding a palladium catalyst and a ligand, so that a mixture A is obtained; secondly, heating the mixture A for carrying out reaction, and then cooling to room temperature, so that a mixture B is obtained; thirdly, diluting the mixture B with ethyl acetate, then filtering the diluted mixture B with diatomite, collecting filtrate, concentrating, and carrying out spin drying, so that the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is obtained. The preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound has the advantages that alkoxycarbonylation reaction on an aromatic heterocycle borate compound or aromatic ring boric acid compound is realized, and the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is directly generated; raw materials are non-toxic, inexpensive and available; a catalytic system is low in cost and has good stability and broad applicability; reaction conditions are mild, safety is high, and control is easy; a technology is simple, operation is easy, environmental friendliness is realized, and specificity is strong, so that the preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is applicable to industrialized production.

Preparation of tert-butyl esters via Pd-catalyzed tert-butoxycarbonylation of (hetero)aryl boronic acid derivatives

A novel protocol to synthesize tert-butyl esters from boronic acids or boronic acid pinacol esters and di-t-butyl dicarbonate has been successfully achieved. The cross-coupling reactions can produce up to 94% yields by using palladium acetate and triphenylphosphine as catalyst system, dioxane as a solvent. Moreover, a wide range of substrates including benzenes, pyridines, and quinolines boronic acids or boronic acid pinacol esters can fit with this system as well.

SEVEN-MEMBERED RING COMPOUND, PRODUCTION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF

A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.