887646-88-0

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 2-[4-(dimethylamino)phenyl]-6-hydroxy-
• CAS NO: 887646-88-0
• Molecular Formula: C17H15NO3
• Molecular Weight: 281.311
• Mol File: 887646-88-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 2-[4-(dimethylamino)phenyl]-6-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 2-[4-(dimethylamino)phenyl]-6-hydroxy-(887646-88-0)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2-[4-(dimethylamino)phenyl]-6-hydroxy-(887646-88-0)

Safety Data

• Hazardous Substances Data: 887646-88-0(Hazardous Substances Data)

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 490-78-8 2,5-Dihydroxyacetophenone 

Downstream Products

• 1254950-57-6 6-(3-bromopropoxy)-2-(4-(dimethylamino)phenyl)-4H-chromen-4-one 
• 1147337-34-5 6-(2-hydroxyethoxy)-4'-dimethylaminoflavone 
• 1147337-36-7 6-(2-(2-hydroxyethoxy)ethoxy)-4'-dimethylaminoflavone 
• 1147337-38-9 6-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-4'-dimethylaminoflavone 

Relevant articles and documents

Scutellarein derivative as well as preparation method and application of scutellarein derivative

The invention belongs to the field of drug synthesis and particularly relates to a scutellarein derivative as well as a preparation method and application of the scutellarein derivative. The scutellarein derivative has a structure shown as the formula 1,

18F-labeled flavones for in vivo imaging of β-amyloid plaques in Alzheimer's brains

In vivo imaging of β-amyloid (Aβ) aggregates in the brain may lead to early detection of Alzheimer's disease (AD) and monitoring of the progression and effectiveness of treatment. The purpose of this study was to develop novel 18F-labeled amyloid-imaging probes based on flavones as a core structure. Fluoropegylated (FPEG) flavone derivatives were designed and synthesized. The affinity of the derivatives for Aβ aggregates varied from 5 to 321 nM. In brain sections of AD model mice, FPEG flavones with the dimethylamino group intensely stained β-amyloid plaques. In biodistrubution experiments using normal mice, they displayed high uptake in the brain ranging from 2.9 to 4.2%ID/g at 2 min postinjection. The radioactivity washed out from the brain rapidly (1.3-2.0%ID/g at 30 min), which is highly desirable for β-amyloid imaging agents. FPEG flavones may be potential PET imaging agents for β-amyloid plaques in Alzheimer's brains.