887757-31-5

Basic information

• Product Name: 4-bromo-3-(bromomethyl)benzoic acid
• Synonyms: 4-bromo-3-(bromomethyl)benzoic acid
• CAS NO: 887757-31-5
• Molecular Weight: 293.942
• Mol File: 887757-31-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-bromo-3-(bromomethyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-3-(bromomethyl)benzoic acid(887757-31-5)
• EPA Substance Registry System: 4-bromo-3-(bromomethyl)benzoic acid(887757-31-5)

Safety Data

• Hazardous Substances Data: 887757-31-5(Hazardous Substances Data)

Upstream product

• 142031-67-2 methyl 4-bromo-3-(bromomethyl)benzoate 
• 7697-28-1 4-bromo-3-methylbenzoic acid 

Downstream Products

• 790230-04-5 4-bromo-3-(hydroxymethyl)benzoic acid 
• 1187239-06-0 C₂₈H₂₇Br₂NO₅S 

Relevant articles and documents

Self-flickering fluorescent dye for super-resolution fluorescence imaging and synthesis and application thereof

The invention provides a self-flickering fluorescent dye for super-resolution fluorescence imaging as well as synthesis and application thereof. According to the dye, azetidine is introduced into the4,5-sites of silicon rhodamine to inhibit intramolecular rotation, so that the characteristics of high quantum yield and high stability are achieved; meanwhile, under normal physiological conditions,fluorescence and non-fluorescence forms of the probe can be mutually converted through intramolecular interaction, so that the probe can be applied to living cell super-resolution imaging, the structural formula of the probe is shown as (1), and the dye can be combined with an antibody to perform specific labeling imaging on tubulin in cells. The dye can be widely applied to the fields of proteinlabeling, super-resolution fluorescence imaging and the like.

Descriptor ΔGC-O Enables the Quantitative Design of Spontaneously Blinking Rhodamines for Live-Cell Super-Resolution Imaging

Herein, we reported a simple, fast, and quantitative theoretical descriptor ΔGC-O that allows accurate predictions of a wide range of spontaneously blinking rhodamines. ΔGC-O denotes the Gibbs free energy differences between the closed and open forms of rhodamines and has a good linear relationship with experimental pKcycl values. This correlation affords an effective guide for the quantitative designs of spontaneously blinking rhodamines and eliminates trial-and-error. We have validated the predictive power of ΔGC-O via the development of two spontaneously blinking rhodamines of different colors and enhanced brightness. We also demonstrated their super-resolution imaging utilities in dynamic live-cell imaging. We expect that ΔGC-O will greatly facilitate the efficient creations of spontaneously blinking fluorophores and aid the advancements of super-resolution bioimaging techniques.

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

A 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented by the generalformula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable saltthereof. They are useful as a therapeutic/preventive agent for diabetes, diabeticnephropathy, or glomerulosclerosis.