887781-86-4Relevant articles and documents
Hydroxytrifluoromethylation of Alkenes Using Fluoroform-Derived CuCF3
Yang, Xinkan,He, Lisi,Tsui, Gavin Chit
, p. 2446 - 2449 (2017)
Hydroxytrifluoromethylation of alkenes using the fluoroform (CF3H)-derived [CuCF3] reagent is described. In the presence of additive B2Pin2 and air, this reagent effectively facilitates the addition of hydroxy and trifluoromethyl groups across an alkene double bond, a formal hydroxytrifluoromethylation process. Various β-trifluoromethyl alcohols can be synthesized from simple alkenes where the ultimate CF3 source is the industrial byproduct fluoroform.
NMP and O2 as Radical Initiator: Trifluoromethylation of Alkenes to Tertiary β-Trifluoromethyl Alcohols at Room Temperature
Liu, Chao,Lu, Qingquan,Huang, Zhiyuan,Zhang, Jian,Liao, Fan,Peng, Pan,Lei, Aiwen
supporting information, p. 6034 - 6037 (2016/01/09)
A novel strategy was developed to trigger ·CF3 by using in situ generated peroxide in NMP under O2 or air as the radical initiator. Radical trifluoromethylation of alkenes was achieved toward tertiary β-trifluoromethyl alcohols. Various tertiary β-trifluoromethyl alcohols can be synthesized in good yields without extra oxidants or transition metal catalysts. Preliminary mechanistic investigation revealed that O2 diffusion can influence the reaction rate.