88784-33-2

Basic information

• Product Name: 1-BENZYL HYDROGEN (S)-4-PHTHALIMIDOGLUTARATE
• Synonyms: 1-BENZYL HYDROGEN (S)-4-PHTHALIMIDOGLUTARATE;(S)-2-(1,3-Dioxo-1,3-dihydroisoindol-2-yl)pentanedioic acid 5-benzyl ester;5-Benzyl (S)-2-phthalimidoglutarate;(S)-5-(Benzyloxy)-2-(1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid;(2S)-2-(1,3-dioxoisoindol-2-yl)-5-oxo-5-phenylmethoxypentanoic acid
• CAS NO: 88784-33-2
• Molecular Formula: C₂₀H₁₇NO₆
• Molecular Weight: 367.35
• Mol File: 88784-33-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 135-136 ºC
• Boiling Point: 588.3°C at 760 mmHg
• Flash Point: 309.6°C
• Appearance: /
• Density: 1.396
• Vapor Pressure: 1.1E-14mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-BENZYL HYDROGEN (S)-4-PHTHALIMIDOGLUTARATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL HYDROGEN (S)-4-PHTHALIMIDOGLUTARATE(88784-33-2)
• EPA Substance Registry System: 1-BENZYL HYDROGEN (S)-4-PHTHALIMIDOGLUTARATE(88784-33-2)

Safety Data

• Hazardous Substances Data: 88784-33-2(Hazardous Substances Data)

Usage

General Description

1-BENZYL HYDROGEN (S)-4-PHTHALIMIDOGLUTARATE is a chemical compound with the molecular formula C17H15NO6. It is a derivative of phthalimide and glutaric acid, with a benzyl group attached to the hydrogen atom of the carboxylic acid. 1-BENZYL HYDROGEN (S)-4-PHTHALIMIDOGLUTARATE is used in organic synthesis and chemical reactions to introduce the benzyl group into molecules. It has potential applications in the pharmaceutical and agrochemical industries, as well as in the production of advanced materials. The compound may also have biological activities and could be of interest in medicinal chemistry research. Overall, 1-BENZYL HYDROGEN (S)-4-PHTHALIMIDOGLUTARATE is a versatile compound with a range of potential applications.

InChI:InChI=1/C20H17NO6/c22-17(27-12-13-6-2-1-3-7-13)11-10-16(20(25)26)21-18(23)14-8-4-5-9-15(14)19(21)24/h1-9,16H,10-12H2,(H,25,26)/t16-/m0/s1

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 621-84-1 O-benzyl carbamate 
• 100-51-6 benzyl alcohol 
• 3343-28-0 N-phthaloylglutamic acid anhydride 
• 85-44-9 phthalic anhydride 
• 1676-73-9 L-glutamic acid γ-benzyl ester 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 25830-77-7 N-phthaloyl-L-glutamic anhydride 

Downstream Products

• 34271-54-0 theanine 
• 109933-17-7 N⁵-phenyl-N²,N²-phthaloyl-DL-glutamine-methyl ester 
• 109933-17-7 N⁵-phenyl-N²,N²-phthaloyl-L-glutamine-methyl ester 
• 88824-62-8 (1S,9S)-t-butyl 9-<(1S)-ethoxycarbonyl-3-phenylpropylamino>octahydro-6,10-dioxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 88767-97-9 (1S,9S)-t-butyl 9-<(1R)-ethoxycarbonyl-3-phenylpropylamino>octahydro-6,10-dioxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 106927-97-3 (1S,9S)-t-butyl octahydro-10-oxo-9-phthalimido-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 106860-19-9 (1S,9S)-t-butyl 9-<(1S)-ethoxycarbonyl-3-phenylpropylamino>octahydro-10-oxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 106860-20-2 9-amino-octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]diazepine-1-(S)carboxylic acid t-butyl ester 
• 88768-40-5 cilazapril 
• 88767-16-2 (S)-4-Chlorocarbonyl-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid benzyl ester 
• 234752-71-7 3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-N-methoxy-N-methyl-succinamic acid tert-butyl ester 
• 192755-43-4 3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-4-oxo-butyric acid tert-butyl ester 
• 192753-53-0 9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid tert-butyl ester 
• 192753-57-4 (1S,9S)-9-Benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF N(5)-ETHYLGLUTAMINE

Disclosed relates to a process for preparing N (5)- ethylglutamines economically without a specific purification process via a simplified and safe process, in which glutamic acid derivatives, represented by formula 1, protected by phthaloyl groups react with ethylamine to cause an amidation and a deprotection reaction in turn under the same reaction condition, thus preparing N (5) -ethylglutamines .

An efficient stereoselective synthesis of [3S(1S,9S)]-3-[[[9- (benzoylamino)octahydro-6,10-dioxo-6H-pyridazino-(1,2-a)(1,2)-diazepin-1- yl]-carbonyl]amino]-4-oxobutanoic acid, an interleukin converting enzyme (ICE) inhibitor

The title compound 1 is a potent interleukin-1β-converting enzyme (ICE) inhibitor. Recently, an efficient chiral synthesis of compound 1 has been accomplished in our labs. The overall yield of this 18-step stereoselective synthesis was 9.8%.

COMPOUNDS CONTAINING A FUSED BICYCLE RING AND PROCESSES THEREFOR

Compounds of the formula STR1 wherein X is O or S--(O) t ; n is one or two; m is zero or one; Y is CH 2, O, or S--(O) t provided that Y is O or S--(O) t only when m is one; and A is STR2 are dual inhibitors of NEP and ACE. Compounds wherein A is STR3 are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.