887936-65-4Relevant articles and documents
Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1 H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombo
Xiong, Yifeng,Teegarden, Bradley R.,Choi, Jin-Sun Karoline,Strah-Pleynet, Sonja,Decaire, Marc,Jayakumar, Honnappa,Dosa, Peter I.,Casper, Martin D.,Pham, Lan,Feichtinger, Konrad,Ullman, Brett,Adams, John,Yuskin, Diane,Frazer, John,Morgan, Michael,Sadeque, Abu,Chen, Weichao,Webb, Robert R.,Connolly, Daniel T.,Semple, Graeme,Al-Shamma, Hussien
experimental part, p. 4412 - 4421 (2010/08/06)
Serotonin, which is stored in platelets and is released during thrombosis, activates platelets via the 5-HT2A receptor. 5-HT2A receptor inverse agonists thus represent a potential new class of antithrombotic agents. Our medicinal pro