887974-64-3 Usage
Description
(6-P-TOLYLPYRIDIN-3-YL)METHANOL, with the molecular formula C14H13NO, is a pyridine derivative characterized by a methyl group at the 6-position and a hydroxyl group at the 3-position of the pyridine ring. This white to light brown solid has a molecular weight of 211.26 g/mol. Its unique molecular structure and functional groups make it a versatile compound in organic synthesis, with potential applications in medicinal chemistry and drug discovery.
Uses
Used in Pharmaceutical Industry:
(6-P-TOLYLPYRIDIN-3-YL)METHANOL is used as a reagent and intermediate for the production of various pharmaceuticals. Its structural features and functional groups contribute to the development of diverse chemical products, making it a valuable component in the synthesis of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, (6-P-TOLYLPYRIDIN-3-YL)METHANOL is utilized as a reagent and intermediate in the synthesis of various agrochemicals. Its unique properties allow for the creation of compounds that can be used in the development of pesticides, herbicides, and other agricultural products.
Used in Organic Synthesis:
(6-P-TOLYLPYRIDIN-3-YL)METHANOL is employed as a key intermediate in organic synthesis, where its molecular structure and functional groups enable the production of a wide range of organic compounds. This versatility makes it a valuable asset in the development of new chemical products across various industries.
Used in Medicinal Chemistry and Drug Discovery:
Due to its structural features, (6-P-TOLYLPYRIDIN-3-YL)METHANOL may have potential applications in medicinal chemistry and drug discovery. Its unique properties could be harnessed to design and develop new therapeutic agents, contributing to the advancement of medical treatments and pharmaceutical innovations.
Check Digit Verification of cas no
The CAS Registry Mumber 887974-64-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,7,9,7 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 887974-64:
(8*8)+(7*8)+(6*7)+(5*9)+(4*7)+(3*4)+(2*6)+(1*4)=263
263 % 10 = 3
So 887974-64-3 is a valid CAS Registry Number.
887974-64-3Relevant articles and documents
Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility
Ang, Chee Wei,Tan, Lendl,Sykes, Melissa L.,Abugharbiyeh, Neda,Debnath, Anjan,Reid, Janet C.,West, Nicholas P.,Avery, Vicky M.,Cooper, Matthew A.,Blaskovich, Mark A. T.
, p. 15726 - 15751 (2020)
Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting additional efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.
