88887-38-1Relevant articles and documents
Methotrexate Analogues. 21. Divergent Influence of Alkyl Chain Length on the Dihydrofolate Reductase Affinity and Cytotoxicity of Methotrexate Monoesters
Rosowsky, Andre,Forsch, Ronald A.,Yu, Cheng-Sein,Lazarus, Herbert,Beardsley, G. Peter
, p. 605 - 609 (2007/10/02)
n-Octyl, n-dodecyl, and n-hexadecyl α- and γ-esters of methotrexate (MTX) were compared with the previously described α- and γ-n-butyl esters and with MTX as inhibitors of dihydrofolate reductase (DHFR) and human leukemic lymphoblasts (CEM cells) in cultu