889131-28-6

Basic information

• Product Name: 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride
• Synonyms: 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride;1,3,4-Oxadiazole-2-carbonyl chloride, 5-methyl-
• CAS NO: 889131-28-6
• Molecular Formula: C₄H₃ClN₂O₂
• Molecular Weight: 146.53182
• Mol File: 889131-28-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 250.0±23.0 °C(Predicted)
• Appearance: /
• Density: 1.445±0.06 g/cm3(Predicted)
• PKA: -5.44±0.10(Predicted)
• CAS DataBase Reference: 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride(889131-28-6)
• EPA Substance Registry System: 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride(889131-28-6)

Safety Data

• Hazardous Substances Data: 889131-28-6(Hazardous Substances Data)

Usage

Description

5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is characterized by its unique 1,3,4-oxadiazole ring structure, which provides a stable and versatile platform for the development of new drugs and other chemical entities.

Uses

Used in Pharmaceutical Industry:
5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride is used as a reagent in the preparation of Raltegravir (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. This novel anti-AIDS drug has shown significant efficacy in treating HIV infections and has become an important component in the development of new antiviral therapies.
Additionally, the compound's 1,3,4-oxadiazole core is a valuable structural motif in medicinal chemistry, as it can be easily modified to create a wide range of biologically active molecules. This makes 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride a valuable building block for the synthesis of new drugs targeting various diseases and conditions.
Used in Agrochemical Industry:
5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride is also used as a key intermediate in the synthesis of agrochemicals, such as insecticides, herbicides, and fungicides. The 1,3,4-oxadiazole ring system can be incorporated into these compounds to enhance their biological activity and selectivity, leading to more effective and environmentally friendly pest control solutions.

Upstream product

• 888504-28-7 5-methyl-1,3,4-oxadiazole-2-carboxylic acid potassium salt 

Downstream Products

• 518048-05-0 raltegravir 
• 1328839-28-6 C₂₄H₂₃FN₈O₇ 
• 1193687-87-4 raltegravir 
• 1391918-18-5 C₃₄H₃₆F₂N₈O₈ 
• 1370588-47-8 methyl 5-(benzoyloxy)-6-methoxy-2-(2-(5-methyl-1,3,4-oxadiazole-2-carboxamido)propan-2-yl)pyrimidine-4-carboxylate 
• 1188424-89-6 N-(4-fluorobenzyl)-3-hydroxy-10-(((5-methyl-1,3,4-oxadiazol-2-yl)carbonyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide 

Relevant articles and documents

Seeking for Selectivity and Efficiency: New Approaches in the Synthesis of Raltegravir

The present work describes the development of an improved synthesis of active pharmaceutical ingredient raltegravir. The isolation of a new process intermediate and the newly developed conditions solve the issue of selectivity typical of this production process, with no need for the use of protecting groups, making the present route more efficient and sustainable than what was reported before. Efficiency comparisons with the previous processes confirm the result here obtained.

Preparation method of pyrimidinone amide type compound

The invention discloses a pyrimidinone amide type compound and a preparation method thereof. A pyrimidinone compound is taken as a starting material and is subjected to four-step chemical conversion to obtain TN-A005 and an analogue thereof, and an intermediate can be prepared from methyl tetrazole. A one-pot method is used for feeding in the whole preparation process, post-treatment purificationof each step is recrystallization or dispersion washing, the use of means such as silica gel column chromatography is avoided, the preparation technology is greatly simplified, the preparation efficiency is improved, and the total yield can reach 50%. The method is simple and convenient in preparation steps and can improve the preparation efficiency.

3. 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application (by machine translation)

The invention discloses 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application. In particular, the invention relates to the formula (I) structure of 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivatives, its stereoisomers or its pharmaceutically acceptable salt, formula (I) in the definition of each substituent is as defined in the specification. These structure of novel compound with heat shock protein HSP90 inhibitory activity, can be used for treating cancer, neurodegenerative diseases, inflammatory diseases, autoimmune diseases, ischemic brain injury and the like, it has broad application prospects. (by machine translation)