88919-22-6 Usage
Description
3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide, also known as Didesmethyl Sumatriptan or Sumatriptan EP Impurity E, is an organic compound that serves as an intermediate in the synthesis of Sumatriptan, a widely used antimigraine drug. It is characterized by its off-white solid appearance and plays a crucial role in the development of effective treatments for migraines.
Uses
Used in Pharmaceutical Industry:
3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide is used as an intermediate in the synthesis of Sumatriptan, an antimigraine agent. It contributes to the production of medications that help alleviate the symptoms of migraines and improve the quality of life for those suffering from this condition.
Used in Antimigraine Applications:
3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide is used as a precursor in the development of Sumatriptan, a medication specifically designed to treat migraines. It plays a vital role in the formulation of drugs that target the underlying causes of migraines, providing relief and reducing the frequency of these debilitating headaches.
Check Digit Verification of cas no
The CAS Registry Mumber 88919-22-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,9,1 and 9 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 88919-22:
(7*8)+(6*8)+(5*9)+(4*1)+(3*9)+(2*2)+(1*2)=186
186 % 10 = 6
So 88919-22-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H17N3O2S/c1-8-3-4-11-10(7-8)9(5-6-13)12(15(11)2)18(14,16)17/h3-4,7H,5-6,13H2,1-2H3,(H2,14,16,17)
88919-22-6Relevant articles and documents
N-Desmethyltriptans: One pot efficient synthesis of N-methyl-2-5- [substituted- 1H- indole-3-yl]ethanamines
Mittapelli, Vasantha,Ray, Puma Chandra,Chauhan, Yogendra Kumar,Datta, Debashish
experimental part, p. 590 - 594 (2010/01/06)
A straightforward and highly improved method to synthesize N-methyl-2-[5-[substituted-lH-indole-3-yl]ethanamines 4-6, which are the metabolites of tryptans 1-3, is reported. The significance of the process is its simplicity and efficiency in isolating the N- desmethyltriptans derivatives as a free base.