88930-14-7

Basic information

• Product Name: H-D-Me-Val-OH
• Synonyms: N-Methyl-D-valine;D-N-Me-val / N-Me-D-val
• CAS NO: 88930-14-7
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.17
• Mol File: 88930-14-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 206.9 °C at 760 mmHg
• Flash Point: 78.9 °C
• Appearance: /
• Density: 0.995
• Vapor Pressure: 0.0935mmHg at 25°C
• Refractive Index: 1.442
• PKA: 2.38±0.13(Predicted)
• CAS DataBase Reference: H-D-Me-Val-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-Me-Val-OH(88930-14-7)
• EPA Substance Registry System: H-D-Me-Val-OH(88930-14-7)

Safety Data

• Hazardous Substances Data: 88930-14-7(Hazardous Substances Data)

Usage

General Description

H-D-Me-Val-OH, also known as N-Methyl-D-valine or N-Methylvaline, is a non-proteinogenic alpha-amino acid commonly found in naturally occurring peptides and antibiotics. It is an optical isomer of the proteinogenic amino acid valine and is used in the synthesis of pharmaceuticals and bioactive compounds. H-D-Me-Val-OH has been shown to possess various biological activities including antimicrobial, antifungal, and antitumor properties, making it a valuable molecule in drug development and medicinal chemistry. Its unique structure and functional properties make it a key component in the study and development of new drugs and therapeutic agents.

InChI:InChI=1/C6H13NO2/c1-4(2)5(7-3)6(8)9/h4-5,7H,1-3H3,(H,8,9)/t5-/m1/s1

Upstream product

• 1494680-68-0 ohmyungsamycin A 

Downstream Products

• 812788-74-2 (3R,6S)-3,6-diisopropyl-4-methyl-2,5-morpholinedione 
• 13850-91-4 Boc-(D,L)-N(Me)-Val-OH 
• 92619-25-5 N-Me-Cbz-valine 
• 812788-12-8 (3S,6R)-3,6-diisopropyl-4-methyl-2,5-morpholinedione 
• 1007880-07-0 2-(benzyl(methyl)amino)-3-methylbutanoic acid trifluoroacetic acid salt 
• 899900-52-8 (R)-2-(N,N-dimethylamino)-3-methylbutanoic acid 
• 847927-42-8 L-DLA-N-Me-D-Val 
• 194736-84-0 FDAA-D-NMe-Val 
• 39554-30-8 NZ-D-Val(Me)-HyiV-OtBu 
• 19892-98-9 O-<(4-Nitro-benzyloxycarbonyl)-N-methyl-D-valin>-D-2-hydroxy-isovaleriansaeure-tert.-butylester 
• 39554-32-0 NZ-D-Val(Me)-HyiV 
• 39606-21-8 NZ-D-Val(Me)-D-HyiV 
• 4530-26-1 NZ-D-Val(Me)-HyiV-Val(Me)-HyiV-D-Val(Me)-D-HyiV-OtBu 
• 4530-26-1 NZ-Val(Me)-HyiV-Val(Me)-HyiV-D-Val(Me)-D-HyiV-OtBu 

Relevant articles and documents

Isolation and Total Synthesis of Mabuniamide, a Lipopeptide from an Okeania sp. Marine Cyanobacterium

The bioassay-guided fractionation of an Okeania sp. marine cyanobacterium collected in Okinawa led to the isolation of the lipopeptide mabuniamide (1). The gross structure of 1 was determined by spectroscopic analyses, and its absolute configuration was determined using Marfey's analysis of the acid hydrolysate of 1. The absolute configuration of 1 was confirmed by total synthesis. Mabuniamide (1) stimulated glucose uptake in cultured rat L6 myotubes. In addition, mabuniamide (1) and its stereoisomer (2) exhibited moderate antimalarial activity.

Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens

A family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, named dudawalamides A-D (1-4), was isolated from a Papua New Guinean field collection of the cyanobacterium Moorea producens using bioassay-guided and spectroscopic approaches. The planar structures of dudawalamides A-D were determined by a combination of 1D and 2D NMR experiments and MS analysis, whereas the absolute configurations were determined by X-ray crystallography, modified Marfey's analysis, chiral-phase GCMS, and chiral-phase HPLC. Dudawalamides A-D possess a broad spectrum of antiparasitic activity with minimal mammalian cell cytotoxicity. Comparative analysis of the Dhoya-containing class of lipopeptides reveals intriguing structure-activity relationship features of these NRPS-PKS-derived metabolites and their derivatives.

Two new 14-membered cyclopeptide alkaloids from Zizyphus xylopyra

The phytochemical investigation of the bark of Zizyphus xylopyra resulted in the isolation of two new 14-membered ring cyclopeptide alkaloids, xylopyrine-G and xylopyrine H. Their structures have been established by chemical and spectral evidences.