88952-74-3

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 6-methyl-2-(4-methylphenyl)-
• CAS NO: 88952-74-3
• Molecular Formula: C17H14O2
• Molecular Weight: 250.297
• Mol File: 88952-74-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 6-methyl-2-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 6-methyl-2-(4-methylphenyl)-(88952-74-3)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 6-methyl-2-(4-methylphenyl)-(88952-74-3)

Safety Data

• Hazardous Substances Data: 88952-74-3(Hazardous Substances Data)

Upstream product

• 4010-25-7 2-acetyl-4-methylphenyl 4-methylbenzoate 
• 60512-56-3 1-(2,2-dibromovinyl)-4-methylbenzene 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 5006-44-0 6-Methyl-4-oxo-4H-1-benzopyran-2-carboxylic acid 
• 5720-05-8 4-methylphenylboronic acid 
• 4714-37-8 1-(2,2-dichlorovinyl)-4-methylbenzene 
• 6627-55-0 2-bromo-p-cresol 
• 201230-82-2 carbon monoxide 
• 766-97-2 4-n-methylphenylacetylene 
• 874-60-2 4-methyl-benzoyl chloride 
• 99-94-5 p-Toluic acid 
• 140-39-6 1-acetoxy-4-methylbenzene 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 106-44-5 p-cresol 

Downstream Products

• 136764-52-8 1a,7a-Dihydro-5-methyl-1a-(4-methylphenyl)-7H-oxireno<1>benzopyran-7-one 
• 118092-42-5 6-Dibromomethyl-2-(4-dibromomethyl-phenyl)-chromen-4-one 
• 78396-37-9 4',6-Dimethyl-3-hydroxyflavone 
• 118092-44-7 2-(4-Formyl-phenyl)-4-oxo-4H-chromene-6-carbaldehyde 

Relevant articles and documents

Rh-Catalyzed aldehydic C-H alkynylation and annulation

Novel Rh-catalyzed aldehydic C-H bond alkynylation and annulation for the in situ synthesis of chromones and aurones are described. It involves the sequential aldehyde C-H bond alkynylation of salicylaldehyde with in situ generated 1-bromoalkyne from 1,1-

A transition-metal-free fast track to flavones and 3-arylcoumarins

A highly regioselective and transition-metal free one-pot arylation of chromenones with arylboronic acids has been achieved employing K2S2O8. The procedure consists of a sequence of some reactions including an arylation/decarboxylation cascade and proceeds well in aqueous media to afford biologically interesting flavones and 3-arylcoumarins. This method exhibited excellent selectivity and functional group tolerance under mild conditions. The reaction also showed perfect efficacy for the preparation of styryl coumarins.

Construction of the flavones and aurones through regioselective carbonylative annulation of 2-bromophenols and terminal alkynes

The easily available and efficient catalyst containing a benzimidazolium ligand and PdCl2(PPh3)2 demonstrated excellent catalytic activity to construct the flavones and aurones, respectively. This reaction can be operated under mild conditions, affording the desired products in moderate to good yields. This protocol was used to prepare the flavones and aurones by a slight modification of amines.