88961-77-7Relevant articles and documents
Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity
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, (2008/06/13)
Aziridine and phenethanolamine derivatives of formulae I and II-1 STR1 wherein R1 and R2 are hydrogen or lower-alkyl; Z1 is phenyl or a phenyl group substituted in a defined manner; Z2 and Z21 are phenyl or thienyl substituted in a defined manner; and, n is an integer from 1-4. The disclosed compounds have catabolic activity and can be used for the treatment of obesity and/or of sugar illnesses. The compounds of formula I are obtained by dehydrating β-aminoalcohols (e.g. those of formula II-1) which, in turn, can be prepared by adding amines to epoxides or by reducing corresponding iminoketones, iminoalcohols a-keto-β-hydroxyamines or β-ketoamines.