890-44-8

Basic information

• Product Name: 1H-Indene-1,3(2H)-dione, 2-(phenylmethyl)-
• CAS NO: 890-44-8
• Molecular Formula: C16H12O2
• Molecular Weight: 236.27
• Mol File: 890-44-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-Indene-1,3(2H)-dione, 2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indene-1,3(2H)-dione, 2-(phenylmethyl)-(890-44-8)
• EPA Substance Registry System: 1H-Indene-1,3(2H)-dione, 2-(phenylmethyl)-(890-44-8)

Safety Data

• Hazardous Substances Data: 890-44-8(Hazardous Substances Data)

Usage

Physical form

Yellow crystalline powder

Common uses

Manufacture of dyes, pigments, and pharmaceuticals

Properties

Anti-inflammatory and antioxidant

Potential applications

Medicinal and cosmetic uses

Role in organic synthesis

Building block for various chemical compounds

Safety precautions

May be harmful if swallowed, inhaled, or comes into contact with the skin

Upstream product

• 109619-58-1 1-Methyl-3-acetyl-4-phenyl-2,5-dioxo-2,3,4,5-tetrahydroindeno<1,2-b>pyridine 
• 5381-33-9 2-benzylidene-indan-1,3-dione 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 131-11-3 phthalic acid dimethyl ester 
• 100-44-7 benzyl chloride 
• 597-55-7 dibenzylmalonic acid diethyl ester 
• 4372-32-1 dibenzylmalonic acid 
• 90787-01-2 1,2-dimethyl-3-ethoxycarbonyl-4-phenyl-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine 

Downstream Products

• 1207202-66-1 (R)-9a-ethyl-1H-fluorene-3,9(2H,9aH)-dione 
• 1207202-60-5 2-benzyl-2-(3-oxobutyl)-1H-indene-1,3(2H)-dione 
• 30251-24-2 2-Allyl-2-benzylindandion-1,3 
• 5381-33-9 2-benzylidene-indan-1,3-dione 
• 140388-99-4 cis,trans-2-benzyl-2-(diphenylmethyl)-2,3-dihydro-1H-indene-1,3-diol 
• 91158-96-2 10-Benzyl-tribenzotricyclo<5.2.1.0.^4,10>decan 
• 91158-87-1 2,2-dibenzyl-2,3-dihydro-1H-indene-1,3-dione 
• 91158-89-3 2-benzyl-2-(diphenylmethyl)-2,3-dihydro-1H-indene-1,3-dione 

Relevant articles and documents

Ruthenium-catalysed C-alkylation of 1,3-dicarbonyl compounds with primary alcohols and synthesis of 3-keto-quinolines

The mono-alkylation of 1,3-diketones using alcohols is possible in the presence of catalytic amounts of Ru(CO)(PPh3)3HCl and 10% mol of the Hantzsch ester. The borrowing hydrogen process between the catalyst and the dihydropyridine/p

Synthesis of novel indane-1,3-dione derivatives and their biological evaluation as anticoagulant agents

2-Substituted derivatives of indane-1,3-dione 3a-f , 5a-g, 6a-g were synthesized and investigated as anticoagulant agents. 2-Arylindane-1,3-diones (3) were obtained in the reaction of phthalide with appropriate arylaldehydes. 2-Arylmethyleneindane-1,3-diones (5) were prepared by condensation of indane-1,3-dione with the corresponding arylaldehydes. The compounds 5 were converted into their methyl analogues 6 by reduction with sodium tetrahydroborate. All of the compounds studied were screened for the anticoagulant activity. The highest prothrombin time was established for 2-[4-(methylsulfanyl) phenyl]indane-1,3-dione (3c) (PT = 33.71 (± 26.01) s), which was very close to PT of the drug anisindione (PT = 36.0 (± 26.42) s).

Towards organo-click reactions: Development of pharmaceutical ingredients by using direct organocatalytic bio-mimetic reductions

Economic and environmentally friendly bio-mimetic one-pot three and four-component Knoevenagel-hydrogenation (K-H), five-component Knoevenagel-hydrogenation-alkylation (K-H-A) and six-component Knoevenagel-hydrogenation-alkylation-Huisgen cycloaddition (K-H-A-HC) reactions of aldehydes, CH-acids, o-phenylenediamine, alkyl halides and azides using proline, proline-metal carbonate and proline-metal carbonate-Cu I-catalysis, respectively have been developed. Many of K-H and K-H-A compounds have direct application in pharmaceutical chemistry. The Royal Society of Chemistry.