89001-53-6

Basic information

• Product Name: 2-METHYL-4-NITROBENZONITRILE 98
• Synonyms: 2-METHYL-4-NITROBENZONITRILE 98;4-Cyano-3-methylnitrobenzene;4-NITRO-2-METHYLPHENYLACETONITRILE;2-Methyl-4-nitrobenzonitrile 98%
• CAS NO: 89001-53-6
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Building Blocks;C8 to C9;Chemical Synthesis;Cyanides/Nitriles;Nitrogen Compounds;Organic Building Blocks
• Mol File: 89001-53-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 100-103 °C(lit.)
• Boiling Point: 329.603 °C at 760 mmHg
• Flash Point: 153.139 °C
• Appearance: white to light yellow crystal powder
• Density: 1.264g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-METHYL-4-NITROBENZONITRILE 98(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-4-NITROBENZONITRILE 98(89001-53-6)
• EPA Substance Registry System: 2-METHYL-4-NITROBENZONITRILE 98(89001-53-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 89001-53-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C8H6N2O2/c1-6-4-8(10(11)12)3-2-7(6)5-9/h2-4H,1H3

Upstream product

• 557-21-1 zinc(II) cyanide 
• 5326-38-5 2-iodo-5-nitrotoluene 
• 557-21-1 dicyanozinc 
• 99-52-5 2-methyl-4-nitro-benzenamine 
• 7149-70-4 2-bromo-5-nitrotoluene 
• 544-92-3 copper(I) cyanide 
• 151-50-8 potassium cyanide 

Downstream Products

• 771574-01-7 (2-methyl-4-nitrophenyl)methanamine 
• 1428765-40-5 N-(2-methyl-4-nitrobenzyl)methanesulfonamide 
• 1428765-41-6 N-(4-amino-2-methylbenzyl)methanesulfonamide 
• 1428765-42-7 phenyl 3-methyl-4-(methylsulfonamidomethyl)phenyl carbamate 
• 72115-06-1 4-amino-2-methylbenzonitrile 
• 1975-51-5 2-methyl-4-nitrobenzoic acid 
• 99584-16-4 2-methyl-4-nitro-benzoic acid amide 
• 610-27-5 4-nitrophthalic acid 
• 72005-84-6 2-methyl-4-nitro-benzaldehyde 
• 1428789-93-8 N-(2-methyl-4-(3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide 
• 1428789-92-7 N-(2-methyl-4-(3-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide 
• 1428764-96-8 N-(2-methyl-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide 
• 1264926-61-5 C₂₉H₃₃N₅O₅ 
• 1264926-59-1 C₃₄H₄₁N₅O₇ 

Relevant articles and documents

Modified Merrifield resin-supported PCP pincer palladium nanoparticles as a new polymeric catalyst for cyanation of aryl iodides

A new tridentate PCP pincer palladium (Pd) complex based on cross-linked Merrifield resin containing phosphinite ligand was synthesized and characterized. This polymeric catalyst was used in preparation of benzonitriles from different aryl iodides using potassium hexacyanoferrate (II) as a cyanide source. The presence of active metallic Pd in the catalyst was verified by X-ray power diffraction and X-ray photoelectron spectroscopy techniques. Transmission electron microscopy showed good dispersion of catalytic sites in the range of 30-50 nm. The catalyst is easily separated from reaction mixture and can be used for several times in repeating cycles without considerable loss of activity. The leaching of Pd from the support is negligible, which was confirmed by inductively coupled plasma-optical emission spectrometry and hot filtration test.

Aryl or N-heteroaryl Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands

The invention relates to aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

AMINE SUBSTITUTED METHANESULFONAMIDE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to amine substituted methanesulfonamide derivatives of formula (I) as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.