890023-59-3Relevant articles and documents
Synthesis and biological activity of pyrido[3′,2′:4,5]thieno[3, 2-d ]pyrimidines as phosphodiesterase type 4 inhibitors
Taltavull, Joan,Serrat, Jordi,Gràcia, Jordi,Gavaldà, Amadeu,Andrés, Míriam,Córdoba, Mònica,Miralpeix, Montserrat,Vilella, Dolors,Beleta, Jorge,Ryder, Hamish,Pagès, Lluís
experimental part, p. 6912 - 6922 (2010/12/25)
A series of pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines (PTP) has been synthesized and tested as phosphodiesterase IV inhibitors (PDE4), a target for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Structure-activity relationships