890098-22-3 Usage
Description
(2-Fluorophenyl)-(2-iodophenyl)-methanone is a chemical compound that features a fluorine-substituted phenyl group and an iodine-substituted phenyl group connected to a central methanone molecule. This unique structure and reactivity make it a valuable building block in organic synthesis and pharmaceutical research. The presence of both fluorine and iodine atoms in the molecule could enhance its lipophilicity or alter its binding affinities, which may be advantageous in drug design and development.
Uses
Used in Organic Synthesis:
(2-Fluorophenyl)-(2-iodophenyl)-methanone is used as a building block for the preparation of complex organic molecules. Its unique structure and reactivity make it a valuable component in the synthesis of various organic compounds.
Used in Pharmaceutical Research:
(2-Fluorophenyl)-(2-iodophenyl)-methanone is used as a pharmaceutical intermediate due to its potential to impart specific properties such as increased lipophilicity or altered binding affinities. These properties may be beneficial in the design and development of new drugs.
Used in Drug Design and Development:
(2-Fluorophenyl)-(2-iodophenyl)-methanone is used as a versatile chemical compound in drug design and development. The combination of fluorine and iodine atoms in the molecule could provide specific advantages, such as improved pharmacokinetics or enhanced target binding, which are crucial for the creation of effective therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 890098-22-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,0,0,9 and 8 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 890098-22:
(8*8)+(7*9)+(6*0)+(5*0)+(4*9)+(3*8)+(2*2)+(1*2)=193
193 % 10 = 3
So 890098-22-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H8FIO/c14-11-7-3-1-5-9(11)13(16)10-6-2-4-8-12(10)15/h1-8H
890098-22-3Relevant articles and documents
Chiral electron-rich PNP ligand with a phospholane motif: Structural features and application in asymmetric hydrogenation
Wang, Heng,Zhang, Yao,Yang, Tilong,Guo, Xiaochong,Gong, Quan,Wen, Jialin,Zhang, Xumu
supporting information, p. 8796 - 8801 (2020/11/13)
Despite the remarkable reactivity that was achieved by a series of transition-metal catalysts with a PNP type ligand, the electron-rich chiral PNP ligands have still been rarely reported because of the difficulties in synthesis and the nature of air-sensitivity. Herein, we report a novel chiral PNP ligand (Heng-PNP) with both a rigid backbone and a bulky tert-butyl group on the phospholane motif. We successfully obtained its divalent iron complex. The chiral environment of its Ir(III) complex was also discussed with quadrant analysis. This tridentate ligand was applied in iridium-catalyzed asymmetric hydrogenation of challenging diaryl ketones: up to 98% ee and 500 TON are achieved. Computational study showed that the twist of conjugate aryl group in the substrate (induced by the special chiral pocket of Ir/Heng-PNP complex) leads to the energy difference in the enantiodetermining step.
