890133-16-1Relevant articles and documents
Piperidine-based renin inhibitors: Upper chain optimization
Corminboeuf, Olivier,Bezenon, Olivier,Remeň, ?ubo?,Grisostomi, Corinna,Richard-Bildstein, Sylvia,Bur, Daniel,Prade, Lars,Strickner, Panja,Hess, Patrick,Fischli, Walter,Steiner, Beat,Treiber, Alexander
scheme or table, p. 6291 - 6296 (2010/12/18)
The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibitor wi
Secondary Amines as Renin Inhibitors
-
Page/Page column 16, (2009/07/18)
The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
HETEROARYL SUBSTITUTED DIAZABICYCLONONENE DERIVATIVES
-
Page/Page column 14, (2010/11/08)
The invention relates to heteroaryl substituted diazabicyclononene derivatives, related compounds and use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for