890139-67-0Relevant articles and documents
Macrocycloadditions leading to conformationally restricted small molecules
Looper, Ryan E.,Pizzirani, Daniela,Schreiber, Stuart L.
, p. 2063 - 2066 (2007/10/03)
The Cu(I)-catalyzed cycloaddition of alkynes and azides (click reaction) provides a robust method for the construction of macrocyclic small molecules via an intramolecular macrocycloaddition. A three-subunit system has been used to explore the tolerance o