890169-52-5Relevant articles and documents
Copper catalysis: One-pot simultaneous synthesis of quinolines and gem-diamine derivatives
Li, Xing-Meng,Tang, Li,Qian, Zhu-Ming,He, Yan-Hong,Guan, Zhi
supporting information, (2020/09/01)
A copper(II)-catalyzed oxidative reaction for the one-pot simultaneous synthesis of quinolines and gem-diamine derivatives from N-arylglycine ethyl esters and enamides is described. In this reaction, the two fragments in an enamide substrate react with th
MYOGLOBIN-BASED CATALYSTS FOR CARBENE TRANSFER REACTIONS
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Paragraph 0071; 00266, (2016/06/14)
Methods are provided for carrying out carbene transfer transformations such as olefin cyclopropanation reactions, carbene heteroatom-H insertion reactions (heteroatom = N, S, Si), sigmatropic rearrangement reactions, and aldehyde olefination reactions with high efficiency and selectivity by using a novel class of myoglobin-based biocatalysts. These methods are useful for the synthesis of a variety of organic compounds which contain one or more new carbon-carbon or carbon-heteroatom (N, S, or Si) bond. The methods can be applied for conducting these transformations in vitro (i.e., using the biocatalyst in isolated form) and in vivo (i.e., using the biocatalyst in a whole cell system).
Cytochrome P450-catalyzed insertion of carbenoids into N-H bonds
Wang, Z. Jane,Peck, Nicole E.,Renata, Hans,Arnold, Frances H.
, p. 598 - 601 (2014/01/17)
Expanding nature's catalytic repertoire to include reactions important in synthetic chemistry will open new opportunities for 'green' chemistry and biosynthesis. We demonstrate the first enzyme-catalyzed insertion of carbenoids into N-H bonds. This type of bond disconnection, which has no counterpart in nature, can be mediated by variants of the cytochrome P450 from Bacillus megaterium. The N-H insertion reaction takes place in water, provides the desired products in 26-83% yield, forms the single addition product exclusively, and does not require slow addition of the diazo component.