89033-27-2Relevant articles and documents
Synthesis method of multi-configuration 2-oxooxazolidine-4-carboxylic acid compound
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Paragraph 0048-0050; 0052-0055, (2020/11/01)
The invention relates to a synthesis method of a multi-configuration 2-oxooxazolidine-4-carboxylic acid compound, wherein the synthesis method comprises the following steps: (1) under the protection of inert gas, carrying out a reaction on a compound represented by a formula I or an isomer thereof with S,S'-dimethyl dithiocarbonate in the presence of water to obtain a compound represented by a formula II or an isomer thereof; (2) carrying out hydrolysis reaction on the compound represented by the formula II or the isomer thereof under an alkaline condition to prepare a compound represented bya formula III or an isomer thereof, wherein the structural formula of the compound represented by the formula I is shown in the specification, the structural formula of the compound represented by theformula II is shown in the specification, the structural formula of the compound represented by the formula III is shown in the specification, in the formula I, the formula II and the formula III, Ris one of H and alkyl with 1-5 carbon atoms. According to the method, water is used as a solvent, so that the method is green, environment-friendly, high in safety, easy in reaction operation and easyin reaction condition control, and the product yield is up to 86% or above.
Enzymatic Production of L-Serine from 2-Oxo-oxazolidine-4-carboxylic Acid
Yokozeki, Kenzo,Majima, Eiji,Izawa, Kunisuke,Kubota, Koji
, p. 963 - 964 (2007/10/02)
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