890656-26-5Relevant articles and documents
Synthesis of Novel Pyrazine-Substituted 1 H -Pyrrole-2-carboxamides and Related Tethered Heterocycles
Borrows, Rachel,Fairley, Gary,Feron, Lyman J. L.,Grant, Emma,Greenwood, Ryan D. R.,Howells, Rachel L.,Hughes, Samantha,Lamont, Scott G.,Lenz, Eva,McGuire, Thomas M.,Simpson, Iain
, (2022/02/10)
As part of a drug discovery program, 4-pyrazin-2-yl-1H-pyrrole-2-carboxamides were accessed along with a number of bicyclic analogues. Routes to these compounds were largely absent from the scientific literature. The synthesis of a 4-(pyrazin-2-yl)-1H-pyrrole-2-carboxamide and several fused bicyclic analogues all using standard procedures (SNAr, borylation, C C cross couplings, hydrolysis, amide bond formation, cyclisation, halogenation, and alkylation) from readily available starting materials is reported. The synthetic sequences range from 4-2 steps per final compound, with yields of isolated intermediates ranging from 20 to ?100%.
Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents
Rochais,Lisowski,Dallemagne,Rault
, p. 8162 - 8175 (2007/10/03)
We herein describe the synthesis of novel 3-(het)aryl-pyrrolo[2,3-b]pyrrolizin-8(1H)-ones starting from commercial (het)aryl-acetonitriles. A more convergent route was also described through the first synthesis of ethyl 3-amino-4-bromo-1H-pyrrole-2-carbox
