89140-85-2

Basic information

• Product Name: 5-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-6-OL
• Synonyms: 5-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-6-OL
• CAS NO: 89140-85-2
• Molecular Formula: C11H15NO
• Molecular Weight: 177.245
• Mol File: 89140-85-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 325.62 °C at 760 mmHg
• Flash Point: 150.73 °C
• Appearance: /
• Density: 1.118 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 5-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-6-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-6-OL(89140-85-2)
• EPA Substance Registry System: 5-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-6-OL(89140-85-2)

Safety Data

• Hazardous Substances Data: 89140-85-2(Hazardous Substances Data)

Usage

General Description

5-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-6-OL, also known as A-838 and GR3027, is a chemical compound with the molecular formula C13H13NO. It is a synthetic tryptamine derivative with psychoactive properties, and it has been studied for its potential as a serotonin receptor agonist. It is structurally related to other psychoactive compounds such as LSD and has been investigated for its potential use in research and therapeutic settings. However, its precise pharmacological effects and potential therapeutic applications are not well understood, and more research is needed to fully elucidate its properties and potential uses.

InChI:InChI=1/C11H15NO/c12-11-9-6-2-1-4-8(9)5-3-7-10(11)13/h1-2,4,6,10-11,13H,3,5,7,12H2

Upstream product

• 4443-71-4 3,4-benzo-1,2-epoxy-1,3-cycloheptadiene 

Relevant articles and documents

BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN

Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

Substitution Reactions Under NH3 Chemical Ionization Conditions in cis-/trans-1,2-Dihydroxybenzosuberans

The nucleophilic substitution reaction under NH3 chemical ionization (CI) conditions in cis- and trans-1,2-dihydroxybenzosuberans (1-4) has benn studied with the help ND3 CI and metastable data.The results indicate that in the parent diols 1 (cis) and 2 (trans), the substitution ion, sH>+, is produced mainly by the loss of H2O from the + ion (SNi reaction) while in their 7-methoxy derivatives 3 and 4, the ion-molecule reaction between + and NH3 seems to be the major pathway for the formation of sH>+.The substitution ion from 1 and 2 and the + ion from trans-1-amino-2-hydroxybenzosuberan give similar collision-induced dissociation mass-analysed ion kinetic energy spectra.Interestingly, their diacetates do not undergo the substitution reaction.