89143-32-8Relevant articles and documents
Conjugate Additions of Amines to Maleimides via Cooperative Catalysis
Uno, Brice E.,Deibler, Kristine K.,Villa, Carlos,Raghuraman, Arjun,Scheidt, Karl A.
supporting information, p. 1719 - 1725 (2018/03/21)
A cooperative system comprising of a lithium Lewis acid and amine base significantly enhances the rate of the conjugate addition of a wide array of amines to maleimides. This operationally simple, scalable method provides mono-addition products in high yields and purity. This conjugation was successfully applied to the kinase inhibitor crizotinib in a chemoselective ligation to create novel fluorescent probe. (Figure presented.).
Synthesis of N-Aryl/substituted-methyl/heteroaryl-&α-pyrrolidino/piperidino Succinimides as Antituberculosis Agents
Rangnekar, V. M.,Lokhande, S. R.,Bhamaria, R. P.,Khadse, B. G.
, p. 1070 - 1071 (2007/10/02)
A series of N-Aryl/substituted-methyl/heteroaryl-α-pyrrolidino- and piperidino-succinimides (II) have been prepared and screened in vitro against H37Rv strain of Mycobacterium tuberculosis.Some of these compounds exhibit activity upto 1.56 μg/ml concentration.