89167-34-0

Basic information

• Product Name: 4-CHLORO-3-IODOPYRIDINE
• Synonyms: 4-CHLORO-3-IODOPYRIDINE;CHLORO-3-IODOPYRIDINE;Pyridine,4-chloro-3-iodo-
• CAS NO: 89167-34-0
• Molecular Formula: C₅H₃ClIN
• Molecular Weight: 239.44
• Product Categories: Pyridine;Pyridines;Heterocycle-Pyridine series;alkyl chloride|alkyl Iodine
• Mol File: 89167-34-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 69-70°C
• Boiling Point: 248.6 °C at 760 mmHg
• Flash Point: 104.1 °C
• Appearance: /
• Density: 2.052 g/cm³
• Vapor Pressure: 0.0379mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.89±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-3-IODOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-IODOPYRIDINE(89167-34-0)
• EPA Substance Registry System: 4-CHLORO-3-IODOPYRIDINE(89167-34-0)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 22-38-41-50
• Safety Statements: 26-39-61
• RIDADR: 3077
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 89167-34-0(Hazardous Substances Data)

Usage

General Description

4-CHLORO-3-IODOPYRIDINE is a chemical compound with the molecular formula C5H3ClIN2. It is a derivative of pyridine and contains both chlorine and iodine atoms in its structure. 4-CHLORO-3-IODOPYRIDINE is used in various chemical reactions and synthesis processes, including in the pharmaceutical industry for the production of pharmaceutical drugs. It is also used as a building block in the synthesis of other organic compounds. 4-CHLORO-3-IODOPYRIDINE may also have applications in the field of agrochemicals and crop protection. Due to its unique structure and reactivity, this chemical is of interest to researchers and chemists for its potential uses in various industrial and scientific applications.

InChI:InChI=1/C5H3ClIN/c6-4-1-2-8-3-5(4)7/h1-3H

Upstream product

• 5570-81-0 1-tert-butyl-4-chloropiperidine 
• 89282-03-1 3-iodo-pyridin-4-ol 
• 1465-76-5 1-tert-butyl-piperidin-4-one 
• 26822-37-7 N,N-dimethyl-4-oxopiperidinium iodide 
• 1445-73-4 1-Methyl-4-piperidone 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 626-61-9 4-Chloropyridine 

Downstream Products

• 1020536-57-5 4-chloro-3-(2-phenylethynyl)pyridine 
• 1203499-10-8 4-benzyloxy-3-iodopyridine 
• 89640-55-1 4-methoxy-3-iodopyridine 
• 612086-27-8 4-chloro-3-(2-phenyl-naphthalen-1-yl)pyridine 
• 1439394-34-9 1-(4-(2-phenyl-1H-pyrrolo[3,2-c]pyridin-1-yl)phenyl)cyclobutanamine 
• 1439394-37-2 tert-butyl 1-(4-(2-phenyl-1H-pyrrolo[3,2-c]pyridin-1-yl)phenyl)cyclobutylcarbamate 
• 1428880-67-4 7-(4-chloropyridin-3-yl)-3-(2-methoxyphenyl)benzo[d]isoxazole 
• 1415818-35-7 3-iodo-4-((1r,4r)-4-(1-methylpiperidin-4-yloxy)cyclohexyloxy)pyridine 
• 1401712-27-3 C₂₄H₁₆ClNO₂ 
• 1034467-33-8 4-chloro-3-trimethylsilylethynyl-pyridine 
• 444989-48-4 2-(4-chloropyridin-3-yl)-phenol 
• 868733-90-8 4-(2-fluoro-4-nitrophenoxy)-3-iodopyridine 
• 656801-24-0 ((S)-1-(4-Chloro-pyridin-3-ylmethyl)-2-{(S)-2-[1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-pyrrolidin-1-yl}-2-oxo-ethyl)-carbamic acid tert-butyl ester 
• 656801-25-1 ((S)-1-(4-Chloro-pyridin-3-ylmethyl)-2-{(R)-2-[1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-pyrrolidin-1-yl}-2-oxo-ethyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula 1: wherein Het, X, R1 and R2 are as defined herein.

Palladium-catalyzed aryl amination-heck cyclization cascade: A one-flask approach to 3-substituted indoles

(Chemical Equation Presented) Two for the price of one: A Pd/dppf-based catalyst provides access to the title compounds from 1,2-dihalogenated aromatic compounds and allylic amines in a single reaction flask. The initial aryl amination step occurs with excellent selectivity for the aryl iodide to ensure the formation of a single indole regioisomer, which can be functionalized in situ by N-arylation (see scheme). dba = dibenzylideneacetone, dppf = 1,1′-bis(diphenylphospanyl)ferrocene.

Deprotonation of chloropyridines using lithium magnesates

Chloropyridines are deprotonated using lithium magnesates. 4-Chloropyridine was deprotonated on treatment with 1/3 equiv of the highly coordinated magnesate Bu3(TMP)MgLi2 in THF at -10°C, as evidenced by trapping with I2. The use of Bu(TMP)2MgLi in Et 2O allowed the reaction of 2-chloropyridine, giving the 3-functionalized derivative as the main product. Mixtures of 3- and 4-functionalized derivatives were obtained when 2,6-dichloropyridine was involved in the reaction. Performing the reaction on 3-chloropyridine with lithium magnesates in THF, either the 4,4′-dimer or the 4-iodo derivative was formed after quenching by I2, the former using 1/3 equiv of Bu2(TMP)MgLi and the latter using 1 equiv of (TMP)3MgLi. Similar results were observed with 3,5-dichloropyridine, 2,5-dichloropyridine and 3-chloro-2-fluoropyridine. 1,2-Migration of the lithium arylmagnesate formed by deprotonation was proposed to justify the dimers formation.