89203-64-5 Usage
Description
3-Pyrrolidineacetic acid, also known as 2-(Pyrrolidin-3-yl)acetic acid, is an organic compound with a pyrrolidine ring and an acetic acid group. It is a versatile building block in the synthesis of various pharmaceutical compounds and has potential applications in the medical field.
Uses
Used in Pharmaceutical Industry:
3-Pyrrolidineacetic acid is used as a key intermediate in the synthesis of Xanthone derivatives for the treatment and prophylaxis of hepatitis B. It plays a crucial role in the development of these therapeutic agents, which can help manage and prevent the spread of the hepatitis B virus.
Used in Chemical Research:
3-Pyrrolidineacetic acid is also used in the preparation of Naphthalenes and Quinolines as ATX modulating agents. These compounds have potential applications in the regulation of lipid metabolism and the treatment of related disorders. The use of 3-Pyrrolidineacetic acid in the synthesis of these agents contributes to the advancement of pharmaceutical research and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 89203-64-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,2,0 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 89203-64:
(7*8)+(6*9)+(5*2)+(4*0)+(3*3)+(2*6)+(1*4)=145
145 % 10 = 5
So 89203-64-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO2/c8-6(9)3-5-1-2-7-4-5/h5,7H,1-4H2,(H,8,9)
89203-64-5Relevant articles and documents
Synthesis of 3-alkylpyrrolidines by anionic cyclization
Coldham, Iain,Hufton, Richard
, p. 12541 - 12552 (1996)
α-Aminocarbanions, generated by transmetallation of aminomethylstannaes, cyclize onto an unactivated alkene to give 3-alkylpyrrolidines. The intermediate organolithium either reincorporates trimethyltin or, from the tributylstannanes, can be trapped with a variety of electrophiles. From the trimethylstannane, the cyclization can be promoted catalytically using 0.2 equivalents of methyllithium. The trimethyltin group in the product can be cleaved using ceric ammonium nitrate. Trapping the 3-lithiomethylpyrrolidine with ethylchloroformate, followed by hydrolysis provides a four step synthesis of the GABA uptake inhibitor 3-pyrrolidineacetic acid.
