89282-09-7

Basic information

• Product Name: 2-Methyloxazole-4-carbonitrile
• Synonyms: 2-Methyloxazole-4-carbonitrile;2-methyl-1,3-oxazole-4-carbonitrile(SALTDATA: FREE)
• CAS NO: 89282-09-7
• Molecular Formula: C₅H₄N₂O
• Molecular Weight: 108.1
• Mol File: 89282-09-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 106-107℃
• Boiling Point: 92℃ (20 Torr)
• Flash Point: 71.0±19.8℃
• Appearance: /
• Density: 1.18±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.457mmHg at 25°C
• Refractive Index: 1.4631 (589.3 nm 20℃)
• CAS DataBase Reference: 2-Methyloxazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyloxazole-4-carbonitrile(89282-09-7)
• EPA Substance Registry System: 2-Methyloxazole-4-carbonitrile(89282-09-7)

Safety Data

• Hazardous Substances Data: 89282-09-7(Hazardous Substances Data)

Usage

General Description

2-Methyloxazole-4-carbonitrile is a chemical compound with the molecular formula C5H4N2O. It is a heterocyclic compound, meaning it contains atoms of at least two different elements in its ring structure. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has also been investigated for its potential biological activities, including antimicrobial, antifungal, and antiviral properties. Additionally, 2-Methyloxazole-4-carbonitrile has been studied for its potential use as a fluorescent probe in various biological and analytical applications. Its distinct chemical structure and properties make it a valuable and versatile compound in the field of organic chemistry.

InChI:InChI=1/C5H4N2O/c1-4-7-5(2-6)3-8-4/h3H,1H3

Upstream product

• 100959-91-9 2-Methyloxazole-4-carboxamide 
• 10200-43-8 2-methyl-4-carbethoxy-1,3-oxazole 
• 109-94-4 formic acid ethyl ester 
• 221558-32-3 5-azido-2-methylthiazole-4-carbaldehyde 
• 73859-07-1 N-cyanomethyl-acetimidic acid ethyl ester 
• 221558-25-4 5-bromo-4-dichloromethyl-2-methylthiazole 
• 221558-28-7 5-bromo-2-methylthiazole-4-carbaldehyde 
• 221558-21-0 4-dichloromethyl-2-methylthiazole 

Downstream Products

• 90980-10-2 2-methyl-oxazole-4-carbothioic acid amide 
• 113732-84-6 2-methyl-1,3-oxazole-4-carbaldehyde 
• 100872-45-5 4-[4-(4-methoxy-phenyl)-thiazol-2-yl]-2-methyl-oxazole 
• 96461-28-8 2-methyl-4-[4-(4-nitro-phenyl)-thiazol-2-yl]-oxazole 
• 96462-75-8 4-[4-(4-bromo-phenyl)-thiazol-2-yl]-2-methyl-oxazole 
• 96583-11-8 4-[4-(4-chloro-phenyl)-thiazol-2-yl]-2-methyl-oxazole 
• 100872-18-2 2-methyl-4-(4-p-tolyl-thiazol-2-yl)-oxazole 
• 106166-86-3 2-methyl-4-(4-phenyl-thiazol-2-yl)-oxazole 

Relevant articles and documents

Large-scale preparation of 2-methyloxazole-4-carboxaldehyde

The large-scale preparation of 2-methyloxazole-4-carboxaldehyde presents a significant challenge due to the physical characteristics of the molecule. A method for the preparation of 10-kg batches of 2-methyloxazole-4-carboxaldehyde is described. The key reaction is the reduction of the corresponding N-methoxy-N-methyl amide using lithium aluminium hydride, followed by workup and isolation by crystallization.

A novel ring transformation of 5-azidothiazoles

The 4-oxoalkyl- and 4-iminoalkyl-5-azidothiazoles undergo a ring transformation with nitrogen loss at relatively low temperatures to afford 4- cyanooxazoles and 4-cyanoimidazoles, respectively. The mechanism, which is thought to involve a ring opening-ring closure process, is discussed.