89283-46-5 Usage
General Description
4-chloro-6-(methylsulfonyl)pyrimidine is a chemical compound with the molecular formula C5H5ClN2O2S. It is a pyrimidine derivative with a chlorine atom and a methylsulfonyl group attached to the 4th and 6th carbon atoms, respectively. 4-chloro-6-(methylsulfonyl)pyrimidine is used as a building block in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used in the manufacture of dyes, pigments, and other specialty chemicals. 4-chloro-6-(methylsulfonyl)pyrimidine is a versatile and important chemical compound with various industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 89283-46-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,2,8 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 89283-46:
(7*8)+(6*9)+(5*2)+(4*8)+(3*3)+(2*4)+(1*6)=175
175 % 10 = 5
So 89283-46-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H5ClN2O2S/c1-11(9,10)5-2-4(6)7-3-8-5/h2-3H,1H3
89283-46-5Relevant articles and documents
HETEROCYCLIC AMIDES AS RIP1 KINASE INHIBITORS
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, (2019/12/15)
Disclosed are compounds having the formula: (I) wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.
Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines
Baiazitov, Ramil,Du, Wu,Lee, Chang-Sun,Hwang, Seongwoo,Almstead, Neil G.,Moon, Young-Choon
, p. 1764 - 1784 (2013/07/26)
Chemoselective SNAr reactions of 4,6-dichloro-2-(methylsulfonyl) pyrimidine and several related electrophiles with amines and their derivatives are described. In the presence of weak bases anilines and secondary aliphatic amines selectively displace the chloride group. Deprotonated anilines and their carbonyl derivatives displace the sulfone group. Sterically and electronically unbiased primary aliphatic amines selectively displace the sulfone group in 4,6-dichloro-2-(methylsulfonyl)pyrimidine; however, their reactions with other electrophiles generally are less selective. Steric-driven selectivity explanation was proposed. Georg Thieme Verlag Stuttgart. New York.
