89371-37-9 Usage
Description
Imidapril is a novel angiotensin-converting enzyme (ACE) inhibitor introduced in Japan as a once-daily treatment for hypertension. It demonstrates more potent inhibitory effects on tissue ACEs from spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) compared to other ACE inhibitors such as enalapril and captopril. Imidapril boasts a notably long duration of action and has been shown to be effective in stroke prevention at lower doses than enalapril, primarily through the amelioration of kidney dysfunction in stroke-prone spontaneously hypertensive rats (SHRSP).
Uses
Used in Pharmaceutical Industry:
Imidapril is used as an antihypertensive agent for the treatment of hypertension. It functions by inhibiting the angiotensin-converting enzyme, which helps lower blood pressure and reduce the risk of stroke.
Used in Cardiovascular Health:
Imidapril is utilized for the prevention of stroke, particularly in stroke-prone spontaneously hypertensive rats (SHRSP). Its effectiveness in stroke prevention is attributed to its indirect mechanism related to the improvement of kidney dysfunction, making it a valuable component in managing cardiovascular health.
Check Digit Verification of cas no
The CAS Registry Mumber 89371-37-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,3,7 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 89371-37:
(7*8)+(6*9)+(5*3)+(4*7)+(3*1)+(2*3)+(1*7)=169
169 % 10 = 9
So 89371-37-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H27N3O6.ClH/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28;/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26);1H/t13-,15-,16-;/m0./s1
89371-37-9Relevant articles and documents
USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS
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, (2008/06/13)
The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R 4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula
ANTIHYPERTENSIVE 2-OXO-IMIDAZOLIDINE DERIVATIVES
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, (2008/06/13)
Novel 2-oxo-imidazolidine derivative of the formula: STR1 wherein R 1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R. sup.3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R 4 is hydrogen or lower alkyl, and a pharmaceutically acceptable salts thereof are disclsoed. Said compounds (I) and salts thereof are useful as hypotensive agents.