894061-98-4

Basic information

• Product Name: (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetamide
• Synonyms: (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetamide
• CAS NO: 894061-98-4
• Molecular Weight: 285.329
• Mol File: 894061-98-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetamide(894061-98-4)
• EPA Substance Registry System: (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetamide(894061-98-4)

Safety Data

• Hazardous Substances Data: 894061-98-4(Hazardous Substances Data)

Upstream product

• 1033038-23-1 ethyl-2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)acetate 

Relevant articles and documents

Anti-HAV activity of some newly synthesized triazolo[4,3-b]pyridazines

6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazine-3(2H)-thione 2 was used as precursor for the preparation of some novel 3-S-substituted-6-phenyl-[1,2,4] triazolo[4,3-b]pyridazine derivatives 3-11. Furthermore, the preparation of 1-[2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetyl] -1H-pyrazole derivative 13 and 5-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3- ylsulfanylmethyl)-[1,3,4]oxadiazole derivatives 15 and 17, are described. Some of the prepared products revealed a promising antiviral activity against hepatitis-A virus (HAV, MBB-cell culture adapted strain). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with the test compounds. Compound 15 showed the highest effect on HAV compared to the other tested compounds.