89407-97-6Relevant articles and documents
Naphthyl urea compound, and preparation method and application thereof
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Paragraph 0047; 0103-0108, (2021/06/21)
The invention provides a naphthyl urea compound, and a preparation method and application thereof. A naphthyl urea parent nucleus group with biological activity contained in the naphthyl urea compound is further chemically modified to generate a plurality of compounds with higher biological activity, so that the wide application of the compounds in biological medicines and the development prospect of pharmaceutical preparations are expanded. The compound can obviously inhibit proliferation of cells of liver cancer, breast cancer, lung cancer, drug-resistant lung cancer, leukemia and the like at low dosage (submicromole), induce arrest of a cell cycle G2/M phase and promote cell apoptosis, so that the compound has a prospect of being developed into an anti-tumor drug.
A novel [...] compound of preparation and its use in cancer therapy (by machine translation)
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Paragraph 0071; 0082-0085, (2019/02/21)
The invention belongs to the field of biology, discloses a new naphthol compound of the design and its preparation method, and this compound or its biological acceptable salt as active ingredient preparation in cell growth control mechanism and application in cancer therapy. Through the biological activity tests show that, the invention relates to the compounds of tumor cells STAT3 cell signal transduction has obvious inhibition effect, and to lung cancer, breast cancer, colon cancer and leukemia such as the proliferation of the cancer cell is obviously antagonistic effect. This class of compounds for the treatment of cancer and cancer clinical potential mechanism to study the significance, with great potential for development, it has very good application prospect. (by machine translation)
A novel salicylic acid derivatives preparation method and its application in treating the tumor
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Paragraph 0018; 0030-0035, (2019/04/10)
The invention belongs to the field of biological medicine, and particularly provides a novel salicylic acid derivatives and application in treating the tumor. We use the chemical synthetic method has been a series of novel salicylic acid derivatives of the compound. We found that the biological activity of the compounds to identify breast cancer, lung cancer, leukemia and other various cell strain has obvious antagonistic effect, we study found that anti-tumor mechanism of the class of compounds STAT3 cell signal transduction have prominent inhibit function, the display of these compounds for the treatment of STAT3 signal conduction abnormality types of cancer has a great significance.