89412-79-3

Basic information

• Product Name: Raddeanin(Anemodeanin) A
• Synonyms: Raddeanin(Anemodeanin) A;anemodeanin A;Raddeanin A;(3beta)-3-[(O-6-Deoxy-alpha-L-mannopyranosyl-(1-2)-O-beta-D-glucopyranosyl-(1-2)-alpha-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid;Raddeanin R3;Raddeanoside R3;2)-a-L-arabinopyranosyl)oxy]-, (3b)-;Olean-12-en-28-oicacid, 3-[(O-6-deoxy-a-L-mannopyranosyl-(1®
• CAS NO: 89412-79-3
• Molecular Formula: C₄₇H₇₆O₁₆
• Molecular Weight: 897.101
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 89412-79-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 242～244℃
• Boiling Point: 967.2 °C at 760 mmHg
• Flash Point: 276.2 °C
• Appearance: /
• Density: 1.36
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Methanol (Slightly), Pyridine (Slightly)
• PKA: 4?+-.0.70(Predicted)
• CAS DataBase Reference: Raddeanin(Anemodeanin) A(CAS DataBase Reference)
• NIST Chemistry Reference: Raddeanin(Anemodeanin) A(89412-79-3)
• EPA Substance Registry System: Raddeanin(Anemodeanin) A(89412-79-3)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 89412-79-3(Hazardous Substances Data)

Usage

Description

Raddeanin(Anemodeanin) A, a triterpenoid saponin, is a bioactive compound known for its anti-tumor properties. It is characterized by its ability to inhibit the proliferation of cancer cells and induce apoptosis, making it a promising candidate for cancer treatment and research.

Uses

Used in Pharmaceutical Industry:
Raddeanin(Anemodeanin) A is used as an anti-tumor agent for its ability to inhibit the proliferation of cancer cells and induce apoptosis. This makes it a potential candidate for the development of cancer treatments and therapies.
Used in Cancer Research:
In the field of cancer research, Raddeanin(Anemodeanin) A is utilized for studying the mechanisms of cancer cell proliferation and apoptosis. Its anti-tumor activity provides valuable insights into the development of novel cancer therapies and understanding the underlying biological processes.
Used in Drug Development:
Raddeanin(Anemodeanin) A is employed in drug development as a potential lead compound for the creation of new anti-cancer drugs. Its unique properties and mechanisms of action can be harnessed to design more effective and targeted cancer treatments.

Upstream product

• 124961-61-1 raddeanoside R₈ 

Relevant articles and documents

Synthesis and biological evaluation of Raddeanin A, a triterpene saponin isolated from Anemone raddeana

First, Raddeanin A, a cytotoxic oleanane-type triterpenoid saponin isolated from Anemone raddeana REGEL, was synthesized. Stepwise glycosylation was adopted in the synthesis from oleanolic acid, employing arabinosyl, glucosyl and rhamnosyl trichloroacetimidate as donors. The chemical structure of Raddeanin A was confirmed by means of 1H-NMR, 13C-NMR, IR, MS and elemental analysis, which elucidated the structure to be 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranoside oleanolic acid. Biological activity tests showed that in the range of low concentrations, Raddeanin A displayed moderate inhibitory activity against histone deacetylases (HDACs), indicating that the HDACs' inhibitory activity of Raddeanin A may contribute to its cytotoxicity.

Saponins from Chinese folk medicine, "zhu jie xiang fu," Anemone raddeana REGEL.

From the Chinese folk medicine "Zhu jie xian fu" (roots of Anemone raddeana REGEL, Ranunculaceae), two new oleanane-type glycosides, named raddeanosides R8 (1) and R9 (2), were isolated. The structures of 1 and 2 were determined as 3-O-alpha-L-rhamnopyranosyl-(1----2)-O-beta-D-glucopyranosyl- (1----2)-alpha-L-arabinopyranosyl oleanolic acid 28-O-alpha-L-rhamnopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----6)-b eta-D- glucopyranoside and 3-O-alpha-L-rhamnopyranosyl-(1----2)-O-beta-D-glucopyranosyl-(1----2)-al pha-L- arabinopyranosyl 27-hydroxyoleanolic acid 28-O-alpha-L-rhamnopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----6)-b eta-D- glucopyranoside, respectively.