894231-51-7

Basic information

• Product Name: C₁₇H₁₆N₄OS
• Synonyms: C₁₇H₁₆N₄OS
• CAS NO: 894231-51-7
• Molecular Weight: 324.406
• Mol File: 894231-51-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₆N₄OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₆N₄OS(894231-51-7)
• EPA Substance Registry System: C₁₇H₁₆N₄OS(894231-51-7)

Safety Data

• Hazardous Substances Data: 894231-51-7(Hazardous Substances Data)

Upstream product

• 56559-62-7 (1-methyl)indole-3-carboxylic acid hydrazide 
• 103-72-0 phenyl isothiocyanate 
• 776-41-0 indole-3-carboxylic acid ethyl ester 
• 56559-60-5 ethyl 1-methyl-1H-indole-3-carboxylate 

Downstream Products

• 1396743-74-0 C₁₇H₁₄N₄S 

Relevant articles and documents

A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents

A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles 6a-v were prepared and studied for their anticancer activity against selected human cancer cell lines. The reaction of indolylhydrazides 3a-h with a variety of aryl isothiocyanates 4 afforded the key intermediate thiosemicarbazides 5a-v, which upon treatment with acetyl chloride produced the 2-arylamino-5-(indolyl)-1,3,4- thiadiazoles 6a-v in good yields. Most of the synthesized compounds showed selective cytotoxicity towards human breast cancer cell line (MDA-MB-231). Of the synthesized 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles, compound 6f is the most potent towards tested cancer cell lines (IC50 = 0.15-1.18 μM).