894414-29-0Relevant articles and documents
Synthesis of fluorescent molecular probes based on cis-cinnamic acid and molecular imaging of lettuce roots
Fukuda, Hiroshi,Nishikawa, Keisuke,Fukunaga, Yukihiro,Okuda, Katsuhiro,Kodama, Kozue,Matsumoto, Kenji,Kano, Arihiro,Shindo, Mitsuru
, p. 6492 - 6498 (2016/09/23)
We synthesized azo dye- and fluorescence-labeled cis-cinnamic acid analogues possessing inhibitory activity against lettuce root growth and a trans-isomer without bioactivity as a control probe. The radicles incubated with the azo dye-labeled analogue were stained red, with their tips especially deeply dyed. The fluorescent images of the radicles incubated with each of these molecular probes depicted that the root cap was fluorescence-stained. However, images of the control radicles prepared by staining with the trans-isomer fluorescent probe did not show emission at the root cap. These contrasts suggest specific localization of the cis-cinnamate analogue at the columella cells.
The synthesis and BK channel-opening activity of N-acylaminoalkyloxime derivatives of dehydroabietic acid
Cui, Yong-Mei,Liu, Xin-Lan,Zhang, Wen-Ming,Lin, Hai-Xia,Ohwada, Tomohiko,Ido, Katsutoshi,Sawada, Kohei
, p. 283 - 287 (2016/01/09)
A series of N-acylaminoalkyloxime derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKα channels. The structure-activity relationship study revealed that a non-covalent interaction between the S atom of the 2-thiophene and the carbonyl O atom may contribute to conformation restriction for interaction with the ion channel. This research could guide the design and synthesis of novel abietane-based BK channel opener.
